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{{short description|Argentine biophysicist}}{{Infobox scientist
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{{Infobox scientist
|name = Ariel Fernandez | image = Dr. Ariel Fernandez, 2016.jpg
| image = Fernandez copy2.tif
| image_size = | image_size =
| alt = | alt =
| caption = | caption = 2016
|birth_date = {{birth date|1957|04|08}} |birth_date = {{birth date and age|1957|04|08}}
|birth_place = ], ] |birth_place = ], Argentina
⚫ |citizenship = {{hlist|Argentina|United States}}
|residence = ], ]
⚫ |field = {{ublist |]|]|]}}
⚫ |citizenship = Argentina, USA
⚫ |alma_mater = {{ublist |]|]}}
|nationality = Argentinian
|doctoral_advisor = ]
⚫ |ethnicity =
| workplaces = {{ublist|]|]}}
⚫ |field = ], ]
|doctoral_students =
⚫ |alma_mater = ]
| thesis_title = Structural Stability of Chemical Systems at Critical Regimes | thesis_title = Structural Stability of Chemical Systems at Critical Regimes
| thesis_url = http://hdl.handle.net/10079/bibid/9852978 | thesis_url = http://hdl.handle.net/10079/bibid/9852978
| thesis_year = 1984 | thesis_year = 1984
| website = {{URL|http://www.profarielfernandez.com/}}
| known_for = ]s
}} }}


'''Ariel Fernandez''' (born '''Ariel Fernández Stigliano''', April 8, 1957) is an ]–] ].<ref name="CV"></ref> '''Ariel Fernandez''' (born '''Ariel Fernández Stigliano''', April 8, 1957) is an Argentinian–American ] and ] researcher.<ref name="CV">{{cite journal|url=https://www.academia.edu/6141377|title=Ariel Fernandez CV and Biographical Narrative|author=Ariel Fernandez|journal=Academia.edu}}</ref>


==Early life, education and early career== ==Education and early career==
Fernandez received a ] degree in Mathematics from the ], Argentina.<ref name="CV" /> He then earned a ] from ] in 1984 with a thesis entitled ''Structural Stability of Chemical Systems at Critical Regimes''<ref name=Diss>Ariel Fernandez. . Published/Created:1984</ref> and was a senior researcher in the division of ] ] at the ] for Biophysical Chemistry in ], ].<ref name="CV" /> He held the Karl F. Hasselmann Professorship of Bioengineering at ].<ref>{{citation|contribution-url=http://www.rice.edu/catalog/2010_2011/PDF/09_AdministrationFaculty.pdf|contribution=Administration and faculty|url=http://www.rice.edu/catalog/2010_2011/|title=Catalog 2010–2011|publisher=Rice University|accessdate=2014-12-02}}.</ref> He is a member of the ] (CONICET) in Argentina.<ref></ref> Fernandez received ] degrees in Chemistry (1979) and Mathematics (1980) from the ], Argentina.<ref name="CV" /> He then earned a ] from ] in 1984 with a thesis entitled ''Structural Stability of Chemical Systems at Critical Regimes''<ref name=Diss>Ariel Fernandez. . Published/Created:1984</ref><ref name="CV" />


==Career== ==Career==
Fernandez held the Karl F. Hasselmann Professorship of Bioengineering at ] until 2011.<ref>{{citation|contribution-url=http://www.rice.edu/catalog/2010_2011/PDF/09_AdministrationFaculty.pdf|contribution=Administration and faculty|url=http://www.rice.edu/catalog/2010_2011/|title=Catalog 2010–2011|publisher=Rice University|accessdate=December 2, 2014|archive-url=https://web.archive.org/web/20141125102257/http://www.rice.edu/catalog/2010_2011/|archive-date=November 25, 2014|url-status=dead}}.{{Dead link|date=October 2022}}</ref>{{Better source needed|date=October 2022}} He is a member of the ] (CONICET) in Argentina.<ref>{{cite web|url=http://www.conicet.gov.ar/new_scp/detalle.php?keywords=&id=33676&datos_academicos=yes|title=Comunicación - Conicet|work=CONICET}}</ref>
Fernandez has published more than 250 articles and has an ] of 25.<ref> Page accessed 5 December 2014</ref> His research spans ], ], ], ] and ].<ref name="CV" /><ref></ref>{{Primary source inline|date=September 2015}}


Fernandez developed the concept of the dehydron, an adhesive structural defect in a soluble ] that promotes its own ].<ref>{{cite journal |journal=] |last=Monroe |first=Dan |title=Proteins Hook up Where Water Allows |year=2012 |volume=5 |issue=51 |page=51 |doi=10.1103/Physics.5.51 |bibcode=2012PhyOJ...5...51M |url=http://physics.aps.org/articles/v5/51 |accessdate=June 23, 2021}}</ref> The ] nature of protein dehydrons has implications for ], as dehydrons may be targeted by highly specific drugs/ligands.<ref>{{cite journal |last=Crunkhorn |first=Sarah |title=Anticancer drugs: Redesigning kinase inhibitors |year=2008 |journal=] |volume=7 |pages=120–121 |doi=10.1038/nrd2524 |s2cid=27083179 |url=http://www.nature.com/nrd/journal/v7/n2/full/nrd2524.html}}</ref> This technology was applied by Fernandez and collaborators to design a new compound based on the anticancer drug ], in order to reduce its ].<ref>Demetri G. D. Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.2007 Dec 3; J Clin Invest. 117(12):3650–3653. doi 10.1172/JCI34252 </ref><ref name="Dunham">Dunham W. Reworked Gleevec curbs heart-related complication. REUTERS December 3, 2007 </ref> In laboratory tests, the new compound was similar to Gleevec in inhibiting ]s, but without toxic effects on cardiac cells, although it lacked Gleevec's inhibitory effects on ] cells.<ref name=Dunham/>
He developed the concept of the dehydron,<ref>Fernández A, Scott R. Dehydron: a structurally encoded signal for protein interaction. Biophys J. 2003 Sep;85(3):1914-28. PMID 12944304 </ref> a structural feature in a ] consisting of an intramolecular ] incompletely shielded from attack by water in the protein's ]. Dehydrons cause "epistructural tension" in proteins and thus promote ] and protein–] associations.<ref>Philip Ball for Nature News. 18 May 2011 </ref> Fernandez is an inventor on a ] for "wrapping technology", which uses the dehydron pattern to design small-molecule inhibitors for rational ].<ref></ref>{{Primary source inline|date=September 2015}}


<!-- This paragraph was added after extensive talk page discussion concluding that it satisfies ] and ]: . If you revise this paragraph, please do not add anything that is contrary to the BLP policy. Please be cautious about reverting this material without prior talk page consensus. -->The editorial board of the '']'' ] a January 2006 paper coauthored by Fernandez because it had "substantial overlap", without attribution, of figures and text from an article by Fernandez published in '']'' the previous month, a form of ].<ref>{{cite journal|title=Retraction for Fernández et al., Packing defects as selectivity switches for drug-based protein inhibitors|first=Nicholas R.|last=Cozzarelli|journal=Proceedings of the National Academy of Sciences, USA|volume=103|issue=11|page=4329|date=March 14, 2006|doi=10.1073/pnas.0601034103|pmid=16505348 |pmc=1449696 |bibcode=2006PNAS..103.4329C |doi-access=free }}</ref> The website ] has documented incidences of scientific concerns about some of Fernandez's other publications, claims that Fernandez has denied.<ref>{{cite journal|url=https://www.chronicle.com/article/meet-retraction-watch-the-blog-that-points-out-the-human-stains-on-the-scientific-record/?cid=reg_wall_signup&bc_nonce=y0vgyz858xcl6uc7u84qx|title=Meet Retraction Watch, the Blog That Points Out the Human Stains on the Scientific Record|first=Steve|last=Kolowich|date=September 25, 2015|journal=The Chronicle of Higher Education}}</ref>
==Awards==
⚫ Fernandez was awarded the ] Distinguished New Faculty in 1989;<ref name="CV" /> the Camille and Henry Dreyfus Teacher-Scholar in 1991;<ref></ref> a ] in 1995;<ref>{{cite web|url=http://www.gf.org/fellows/4491-ariel-fernandez |title=Ariel Fernández |work=Fellows |publisher=John Simon Guggenheim Memorial Foundation |accessdate=27 September 2012}}</ref> and is an Elected Fellow, ] (2006).<ref>{{cite web|url=http://aimbe.org/college-of-fellows/cof-0289/ |title=College of Fellows |work=Members |publisher=American Institute for Medical and Biological Engineering |accessdate=27 September 2012}}</ref>


==Published works== ==Awards==
⚫ Fernandez was awarded a ] for early-career researchers in 1991;<ref>{{Cite web |url=http://www.dreyfus.org/announcements/PAST-TC.pdf |title=Camille Dreyfus Teacher-Scholar Awards Program Past Awards |access-date=December 3, 2014 |archive-url=https://web.archive.org/web/20160705210425/http://www.dreyfus.org/announcements/PAST-TC.pdf |archive-date=July 5, 2016 |url-status=dead }}</ref> a ] for researchers in Latin America and the Caribbean in 1995;<ref>{{cite web|url=http://www.gf.org/fellows/all-fellows/ariel-fernandez/ |title=Ariel Fernández |work=Fellows |publisher=John Simon Guggenheim Memorial Foundation |accessdate=September 27, 2012}}</ref> and was elected a Fellow of the ] for his "contributions to understanding protein folding and protein-protein interactions and the use of this knowledge to design new drugs", in 2006.<ref>{{cite web|url=http://aimbe.org/college-of-fellows/cof-0289/ |title=College of Fellows |work=Members |publisher=American Institute for Medical and Biological Engineering |accessdate=September 27, 2012}}</ref>
⚫ * ''Transformative Concepts for Drug Design: Target Wrapping'', by Ariel Fernandez (ISBN 978-3642117916, Springer-Verlag, Berlin, Heidelberg, 2010).<ref>{{cite web|url=http://arielfernandez.net/bibliography.html |title=Ariel Fernandez Bibliography |accessdate=25 February 2014}}</ref>
* {{cite book |last= |first= |date=2015 |title=Biomolecular Interfaces |url=https://www.springer.com/la/book/9783319168494 |location=Berlin, Heidelberg |publisher=Springer-Verlag |page= |isbn=9783319168494}}


==See also== ==Books==
⚫ * ''Transformative Concepts for Drug Design: Target Wrapping'', by Ariel Fernández ({{ISBN|978-3642117916}}, Springer-Verlag, Berlin, Heidelberg, 2010).
*] (Fernandez' dissertation advisor<ref name=Diss/>)
* ''Biomolecular Interfaces'', by Ariel Fernández Stigliano ({{ISBN|978-3319168494}}, Springer-Verlag, Berlin, Heidelberg, 2015).
* ''Physics at the Biomolecular Interface'', by Ariel Fernández ({{ISBN|978-3319308517}}, Springer International Publishing AG, Switzerland, 2016).<ref>{{cite journal | last = Dobson | first = Peter J. | date = September 2017 | bibcode = 2017ConPh..58..369D | doi = 10.1080/00107514.2017.1371227 | issue = 4 | journal = Contemporary Physics | pages = 369 | publisher = Informa {UK} Limited | title = Review of ''Physics at the Biomolecular Interface'' | volume = 58| s2cid = 126086755 }}</ref>
* ''A Mathematical Approach to Protein Biophysics'', by L. Ridgeway Scott and Ariel Fernández ({{ISBN|978-3319660318}}, Springer, 2017).
* ''Artificial Intelligence Platform for Molecular Targeted Therapy: A Translational Science Approach'', by Ariel Fernández ({{ISBN|978-9811232305}}, World Scientific Publishing Co., 2021).
* ''Topological Dynamics in Metamodel Discovery with Artificial Intelligence: From Biomedical to Cosmological Technologies'', by Ariel Fernández ({{ISBN|978-1032366326}}, Chapman & Hall/CRC Press, UK, 2022).
* ''Artificial Intelligence on Dark Matter and Dark Energy: Reverse Engineering of the Big Bang'', by Ariel Fernández ({{ISBN|978-1032465548}}, Chapman & Hall/CRC Press, UK, 2023).


==References== ==References==
{{reflist|2}} {{reflist|2}}


==External links==
*


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Latest revision as of 21:43, 6 September 2023

Argentine biophysicist
Ariel Fernandez
2016
Born (1957-04-08) April 8, 1957 (age 67)
Bahía Blanca, Argentina
Citizenship
  • Argentina
  • United States
Alma mater
Known forDehydrons
Scientific career
Fields
Institutions
ThesisStructural Stability of Chemical Systems at Critical Regimes (1984)
Doctoral advisorOktay Sinanoğlu
Websitewww.profarielfernandez.com

Ariel Fernandez (born Ariel Fernández Stigliano, April 8, 1957) is an Argentinian–American physical chemist and pharmaceutical researcher.

Education and early career

Fernandez received Licentiate degrees in Chemistry (1979) and Mathematics (1980) from the Universidad Nacional del Sur, Argentina. He then earned a Ph.D. from Yale University in 1984 with a thesis entitled Structural Stability of Chemical Systems at Critical Regimes

Career

Fernandez held the Karl F. Hasselmann Professorship of Bioengineering at Rice University until 2011. He is a member of the National Scientific and Technical Research Council (CONICET) in Argentina.

Fernandez developed the concept of the dehydron, an adhesive structural defect in a soluble protein that promotes its own dehydration. The nonconserved nature of protein dehydrons has implications for drug discovery, as dehydrons may be targeted by highly specific drugs/ligands. This technology was applied by Fernandez and collaborators to design a new compound based on the anticancer drug Gleevec, in order to reduce its cardiotoxicity. In laboratory tests, the new compound was similar to Gleevec in inhibiting gastrointestinal stromal tumors, but without toxic effects on cardiac cells, although it lacked Gleevec's inhibitory effects on leukemia cells.

The editorial board of the Proceedings of the National Academy of Sciences retracted a January 2006 paper coauthored by Fernandez because it had "substantial overlap", without attribution, of figures and text from an article by Fernandez published in Structure the previous month, a form of duplicate publication. The website Retraction Watch has documented incidences of scientific concerns about some of Fernandez's other publications, claims that Fernandez has denied.

Awards

Fernandez was awarded a Camille Dreyfus Teacher-Scholar Award for early-career researchers in 1991; a Guggenheim Fellowship for researchers in Latin America and the Caribbean in 1995; and was elected a Fellow of the American Institute for Medical and Biological Engineering for his "contributions to understanding protein folding and protein-protein interactions and the use of this knowledge to design new drugs", in 2006.

Books

  • Transformative Concepts for Drug Design: Target Wrapping, by Ariel Fernández (ISBN 978-3642117916, Springer-Verlag, Berlin, Heidelberg, 2010).
  • Biomolecular Interfaces, by Ariel Fernández Stigliano (ISBN 978-3319168494, Springer-Verlag, Berlin, Heidelberg, 2015).
  • Physics at the Biomolecular Interface, by Ariel Fernández (ISBN 978-3319308517, Springer International Publishing AG, Switzerland, 2016).
  • A Mathematical Approach to Protein Biophysics, by L. Ridgeway Scott and Ariel Fernández (ISBN 978-3319660318, Springer, 2017).
  • Artificial Intelligence Platform for Molecular Targeted Therapy: A Translational Science Approach, by Ariel Fernández (ISBN 978-9811232305, World Scientific Publishing Co., 2021).
  • Topological Dynamics in Metamodel Discovery with Artificial Intelligence: From Biomedical to Cosmological Technologies, by Ariel Fernández (ISBN 978-1032366326, Chapman & Hall/CRC Press, UK, 2022).
  • Artificial Intelligence on Dark Matter and Dark Energy: Reverse Engineering of the Big Bang, by Ariel Fernández (ISBN 978-1032465548, Chapman & Hall/CRC Press, UK, 2023).

References

  1. ^ Ariel Fernandez. "Ariel Fernandez CV and Biographical Narrative". Academia.edu.
  2. Ariel Fernandez. Yale University Dissertation: Structural Stability of Chemical Systems at Critical Regimes (Dissipative Structures, Potential Energy Surfaces). Published/Created:1984
  3. "Administration and faculty", Catalog 2010–2011, Rice University, archived from the original (PDF) on November 25, 2014, retrieved December 2, 2014.
  4. "Comunicación - Conicet". CONICET.
  5. Monroe, Dan (2012). "Proteins Hook up Where Water Allows". Physics. 5 (51): 51. Bibcode:2012PhyOJ...5...51M. doi:10.1103/Physics.5.51. Retrieved June 23, 2021.
  6. Crunkhorn, Sarah (2008). "Anticancer drugs: Redesigning kinase inhibitors". Nature Reviews Drug Discovery. 7: 120–121. doi:10.1038/nrd2524. S2CID 27083179.
  7. Demetri G. D. Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.2007 Dec 3; J Clin Invest. 117(12):3650–3653. doi 10.1172/JCI34252
  8. ^ Dunham W. Reworked Gleevec curbs heart-related complication. REUTERS December 3, 2007
  9. Cozzarelli, Nicholas R. (March 14, 2006). "Retraction for Fernández et al., Packing defects as selectivity switches for drug-based protein inhibitors". Proceedings of the National Academy of Sciences, USA. 103 (11): 4329. Bibcode:2006PNAS..103.4329C. doi:10.1073/pnas.0601034103. PMC 1449696. PMID 16505348.
  10. Kolowich, Steve (September 25, 2015). "Meet Retraction Watch, the Blog That Points Out the Human Stains on the Scientific Record". The Chronicle of Higher Education.
  11. "Camille Dreyfus Teacher-Scholar Awards Program Past Awards" (PDF). Archived from the original (PDF) on July 5, 2016. Retrieved December 3, 2014.
  12. "Ariel Fernández". Fellows. John Simon Guggenheim Memorial Foundation. Retrieved September 27, 2012.
  13. "College of Fellows". Members. American Institute for Medical and Biological Engineering. Retrieved September 27, 2012.
  14. Dobson, Peter J. (September 2017). "Review of Physics at the Biomolecular Interface". Contemporary Physics. 58 (4). Informa {UK} Limited: 369. Bibcode:2017ConPh..58..369D. doi:10.1080/00107514.2017.1371227. S2CID 126086755.


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