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{{short description|Canadian biomedical engineer}}
{{peacock|date=February 2018}}
{{Infobox scientist {{Infobox scientist
| name = Jeff Karp | name = Jeff Karp
| birth_date = {{Birth year and age|1975}}
⚫ | image = Jeffrey Karp.jpg
| caption = Jeffrey Karp | image = Jeffrey Karp.jpg
⚫ | caption = Jeffrey Karp
| residence = United States
| nationality = Canada | nationality = Canadian
| field = ], ], ], ] | field = ]
| work_institution = ], ] | work_institution = ], ]
| alma_mater = ], ], ] | alma_mater = ], ], ]
| doctoral_advisor = John Davies & ] | doctoral_advisor = John Davies & ]
| academic_advisors = ] | academic_advisors = ]
| footnotes = | footnotes =
}} }}
'''Jeff Karp''' is a Canadian–born ]. He is a Professor of Medicine at ], ], and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the ] through the ]. He is also an affiliate faculty at the ]. '''Jeffrey Karp''' (born 1975)<ref>{{Cite web|url=http://www2.technologyreview.com/tr35/profile.aspx?TRID=722|title=Innovator Under 35: Jeffrey Karp, 32|first=MIT Technology|last=Review|website=MIT Technology Review}}{{Dead link|date=August 2024 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> is a Canadian ] working as a Professor of Medicine at ], ], and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the ] through the ]. He is also an affiliate faculty at the ].

Karp has co-founded six medical companies, including , which develops products for those with skin ailments or damaged/sensitive skin, which develops ]s (a type of surgical glue intended to augment or replace ]), , which develops inflammation targeting and inflammation responsive materials for treating inflammatory diseases, , which focuses on medical treatment for chronic hearing loss, and Landsdowne Labs, which focuses on improving the safety of children. Karp's companies collectively have raised >$100,000,000 and employ >70 people. In 2008 MIT's ] listed him as one of the top innovators in the world under the age of 35 (]). In 2014, Skintifique brought four consumer healthcare products to market that are sold in pharmacies throughout Europe and are globally available. In 2017, Gecko Biomedical received European regulatory approval (CE mark) for its first tissue sealant product and was recognized by Fierce Medtech as part of their Fierce 15 list of 2017. Frequency Therapeutics began human clinical testing in 2017 for its lead program to treat chronic hearing loss and has completed a successful phase I safety study in Australia.


==Education== ==Education==
Jeff was born and raised in ], graduating from ]. He graduated from ] in 1999 with a degree in chemical engineering.<ref>{{cite news |url=http://www.thepeterboroughexaminer.com/ArticleDisplay.aspx?e=620525&archive=true |title=Crestwood grad to teach at Harvard; Peterborough native hired to research regenerative medicine, including therapies based on stem cells |last=Houston |first=Andrea |year=2008 |work=The Peterborough Examiner |accessdate=30 May 2012}}</ref> At McGill he was elected to the McGill Senate to represent over 2000 students, he was also a nominated member of the McGill Admissions Committee, the Advisory Committee to Select a new dean of Engineering, and the Student Affairs Senate Sub-Committee. While at McGill he also co-founded the McGill Engineering Code of Ethics "The Blueprint".<ref>http://reporter-archive.mcgill.ca/Rep/r3111/blueprint.html</ref> Karp was born and raised in ].<ref>{{cite news|title=Parasite inspires new research for Harvard scientist from Peterborough|url=https://www.thepeterboroughexaminer.com/news-story/8203173-parasite-inspires-new-research-for-harvard-scientist-from-peterborough/|work=The Peterborough Examiner|date=16 October 2013|archiveurl=https://web.archive.org/web/20180303033016/https://www.thepeterboroughexaminer.com/news-story/8203173-parasite-inspires-new-research-for-harvard-scientist-from-peterborough/|archivedate=3 March 2018|language=en-CA}}</ref> He graduated from ] in 1999 with a degree in chemical engineering.<ref name=McGillAlum>{{cite web|title=Alumni|url=https://www.mcgill.ca/chemeng/about-us/alumni|website=Chemical Engineering|accessdate=3 March 2018|language=en}}</ref> While at McGill he also co-founded the McGill Engineering Code of Ethics "The Blueprint".<ref>{{cite news|title=Reporter: The Blueprint|url=http://reporter-archive.mcgill.ca/Rep/r3111/blueprint.html|work=McGill Reporter|date=25 February 1999}}</ref>


He received a ] in Chemical and Biomedical Engineering from the ] in 2004.<ref name=McGillAlum/>
He received a ] in Chemical and Biomedical Engineering from the ] in 2004.<ref>{{cite web |url=http://www.hsci.harvard.edu/people/jeffrey-karp-phd |title=Jeffrey Karp, PhD |work=Harvard Stem Cell Institute |accessdate=28 May 2012}}</ref> While at the University of Toronto, he was head TA{{clarify|date=July 2012}} for the Faculty of Engineering, an active member of the Engineering Teaching Committee, and a board member of the Toronto chapter for the Canadian Biomaterials Society. He also actively volunteered on the ] ward at the Hospital for Sick Children, and worked part-time for MadScience, a hands-on teaching program to spark the imagination and curiosity of elementary students.<ref>http://www.madscience.org/locations/toronto/</ref>


From 2004 until 2006, Karp was a postdoctoral fellow in ]'s laboratory at MIT in the ];<ref>{{cite web|title=Karp Biosketch|url=http://hst.mit.edu:80/public/people/faculty/facultyBiosketch.jsp?key=Karp|publisher=Harvard-MIT Division of Health Sciences and Technology|archiveurl=https://web.archive.org/web/20090626011933/http://hst.mit.edu/public/people/faculty/facultyBiosketch.jsp?key=Karp|archivedate=26 June 2009|access-date=2 February 2020|url-status=live}}</ref> Karp had applied for the position but Langer had no funds to pay him, so Karp secured funding from the ] and Langer accepted him.<ref name=Godfrey>{{cite news|last1=Godfrey|first1=Rena|title=The Bioinspirationalist: Dr. Jeffrey Karp looks to nature to solve big medical issues|url=http://www.renagodfrey.com/jeff-karp/|work=Rena Godfrey's Lifestyles Magazine|date=24 July 2017}}</ref>
From 2004 until 2007, Karp was an ] postdoctoral fellow in ]'s laboratory at MIT.<ref>http://web.mit.edu/newsoffice/2008/adhesive-0218.html</ref>

==Personal==
Karp resides in ] with his wife, two children, and his two ].<ref name = "BBJ" />


==Research== ==Research==
In the Langer lab, Karp was inspired by another lab's publication in ''Nature'' that described adhesives based on the way that ]'s feet stick to surfaces; he and Langer applied for funding from NSF to make medical adhesives based on geckos, and received the funding.<ref name=Godfrey/>
His research has led to several products on the market, and a number that are under clinical development. His most noticeable work includes bioinspired tissue adhesives to augment or replace sutures and staples,<ref>{{cite journal |last=Mahdavi |first=Aborz |date=February 19, 2008 |title=A biodegradable and biocompatible gecko-inspired tissue adhesive |journal=] |volume=105 |pages=2307–2312 |url=http://www.pnas.org/content/105/7/2307.short |doi=10.1073/pnas.0712117105|display-authors=etal |pmid=18287082 |pmc=2268132}}</ref><ref>{{cite news |url=http://www.wbur.org/npr/19279821/gecko-toes-inspire-design-of-new-medical-bandage |title=Gecko Toes Inspire Design of New Medical Bandage |date=February 22, 2008 |work=] |accessdate=30 May 2012}}</ref> engineered stem cell homing,<ref>{{cite journal |last=Karp |first=Jeffrey M. |author2=Grace Sock |author3=Leng Teo |date=March 6, 2009 |title=Mesenchymal Stem Cell Homing: The Devil Is in the Details |journal=] |publisher=Elsevier |volume=4 |issue=3 |pages=206–216 |url=http://www.cell.com/cell-stem-cell/retrieve/pii/S1934590909000563 |doi=10.1016/j.stem.2009.02.001}}</ref><ref>{{cite news |url=http://www.sflorg.com/comm_center/unv_medical/p672_141.html |title=Simple Chemical Procedure Augments Therapeutic Potential of Stem Cells |date=October 31, 2008 |work=Scientific Frontline |accessdate=30 May 2012}}</ref> cell surface sensors,<ref>{{cite journal |last=Zhao |first=Weian |author2=Jeffrey Karp|date=July 17, 2011 |title=Cell-surface sensors for real-time probing of cellular environments |journal=Nature Nanotechnology |publisher=Nature Publishing Group |volume=6 |pages=524–532 |url=http://www.cell.com/cell-stem-cell/retrieve/pii/S1934590909000563 |doi=10.1038/nnano.2011.101|display-authors=etal}}</ref> a needle that automatically stops when it gets to the right location,<ref name = "BBJ" /> and inflammation responsive drug release.


In 2007 he received an appointment and his own lab at ], at a location near MIT; he retained his association with the Harvard–MIT HST program.<ref name=Guardian/> He has made mentoring high school students, undergraduates, PhD students, and post docs a priority, and in 2008 he won the Outstanding Undergraduate Student Mentor Award at MIT,<ref>{{cite news|title=Prof. Jeff Karp and his gecko-inspired band-aid|url=http://mitadmissions.org/blogs/entry/prof_jeff_karp_and_his_geckoin_1|work=MIT Admissions|date=May 31, 2008|language=en}}</ref> and in 2010 he won the Thomas A. McMahon Mentoring Award from the HST program.<ref>{{cite web|title=Thomas A. McMahon Mentoring Award {{!}} Harvard-MIT Health Sciences and Technology|url=http://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award|publisher=Harvard-MIT HST Program|accessdate=3 March 2018|language=en|archive-date=5 March 2016|archive-url=https://web.archive.org/web/20160305081941/http://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award|url-status=dead}}</ref>
⚫ ==Recognition==


In 2013 the company Gecko Biomedical was founded based on the gecko adhesive work, as well as subsequent work done in the Karp lab based on secretions of ]s.<ref name=Guardian>{{cite news|last1=Parker|first1=Laura|title=Inspired by nature: the thrilling new science that could transform medicine|url=https://www.theguardian.com/science/2016/oct/25/bioinspiration-thrilling-new-science-could-transform-medicine|work=The Guardian|date=25 October 2016|language=en}}</ref>
Karp has published more than 100 peer-reviewed papers (with 13,000 citations) and book chapters and has given over 250 national and international invited lectures and has >100 issued or pending patents. Several technologies that he has invented are currently being translated into medical products to improve the quality of life of suffering patients. Dr. Karp's work has been recognized by CNN, NPR Science Fridays, Boston Globe, ABC News, MSNBC, Fox News, CBC Quirks and Quarks, CanadaAM, BBC, LA Times, Forbes, National Geographic, Popular Science, the Washington Post, the New York Post, and by Wired Magazine.


In 2014 the company Skintifique was formed to commercialize a barrier cream Karp had invented to prevent skin reactions in people with ].<ref>{{cite journal|last1=Fischer|first1=S|title=At the interface of disciplines: Jeffrey Karp pulls from nature and nano to transform medicine.|journal=IEEE Pulse|date=2014|volume=5|issue=2|pages=30–3|doi=10.1109/MPUL.2013.2296799|pmid=24625588|s2cid=21924036}}</ref>
To date, 18 trainees from his laboratory have secured faculty positions at institutions throughout the world.


In 2015 the company Frequency Therapeutics was founded to create treatments for hearing loss based on work done by Langer and Karp inspired by the ability of some amphibians and birds to regrow hair cells that have been damaged.<ref>{{cite news|title=Frequency, Led by MIT's Langer, Aims to Fight Hearing Loss With Drugs|url=https://www.xconomy.com/boston/2017/01/05/frequency-led-by-mits-langer-aims-to-fight-hearing-loss-with-drugs/|work=Xconomy|date=5 January 2017}}</ref>
Among other honors, Karp was elected as a new fellow in the American Institute for Medical and Biological Engineering's (AIMBE) College of Fellows. The College of Fellows is composed of about 1,000 (top 2%) of the country’s most outstanding biomedical and biological engineers in academia, industry, and government. Karp also received the 2011 Young Investigator award from the ],<ref>http://hst.mit.edu/news-and-events/society-biomaterials-young-investigator-award-goes-jeffrey-karp-and-ali</ref> and '']'' listed him in 2008 as one of the top innovators under the age of 35 (]).<ref>{{cite web|url=http://www.technologyreview.com/tr35/?year=2008 |title=2008 Top 35 Innovators Under 35 |publisher=] | year=2008 | accessdate=August 14, 2011}}</ref>


In 2016 the company Alivio Therapeutics was founded based on work by Langer and Karp on a hydrogel to deliver drugs, intended to stick to tissue and only release the drug in response to inflammation.<ref>{{cite news|last1=Adams|first1=Ben|title=Fresh from a new CAR-T biotech, PureTech launches Alivio Therapeutics|url=https://www.fiercebiotech.com/biotech/fresh-from-a-new-car-t-biotech-puretech-launches-alivio-therapeutics|work=FierceBiotech|date=May 10, 2016|language=en}}</ref>
His laboratory has been funded by multiple companies, foundations and governmental funding agencies including the Bill and Melinda Gates Foundation, NFL, Johnson & Johnson, Phillips, Sanofi, UCB, NIH, DOD, US Army, Kenneth Rainin Foundation, Helmsley Trust, JDRF, Rheumatology Research Foundation, Coulter Foundation, Prostate Cancer Foundation, Brain Science Foundation, American Heart Association, Deshpande Foundation, Institute for Pediatric Innovation, Boston Children’s Hospital, Brigham and Women’s Hospital, the Government of India and the Government of Korea. Dr. Karp also won an internal Shark Tank award judged by Kevin O’Leary.


⚫ ==Recognition==
Karp is a popular mentor in the MIT and Harvard community.<ref name="McMahon Mentoring Award">{{cite news |url=https://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award}}</ref> He was selected as the Outstanding Faculty Undergraduate Mentor at MIT in 2008 and in 2010 the Harvard-MIT division HST granted him the McMahon Mentoring award as top mentor.<ref>http://hst.mit.edu/people/faculty/awards/thomas-mcmahon-mentoring-award</ref>
'']'' listed him in 2008 as one of the top innovators under the age of 35 (]).<ref>{{cite web|url=http://www.technologyreview.com/tr35/?year=2008 |title=2008 Top 35 Innovators Under 35 |publisher=] | year=2008 | accessdate=August 14, 2011}}</ref> Karp received the 2011 Young Investigator award from the Society for Biomaterials,<ref>{{cite news|title=Press Release: Two from Brigham and Women's Hospital Receive Society for Biomaterials Young Investigator Award|url=https://www.brighamandwomens.org/about_bwh/publicaffairs/news/pressreleases/PressRelease.aspx?sub=0&PageID=775|work=Brigham and Women's Hospital|date=9 December 2010|archiveurl=https://web.archive.org/web/20110624091914/https://www.brighamandwomens.org/about_bwh/publicaffairs/news/pressreleases/PressRelease.aspx?sub=0&PageID=775|archivedate=24 June 2011}}</ref> and also in 2011, the '']'' profiled him as a Champion in Health Care Innovation.<ref name="BBJ">{{cite news |url=http://www.bizjournals.com/boston/print-edition/2011/08/26/champions-in-health-care-jeffrey.html |title=Champions in Health Care: Jeffrey Karp, innovator |last=Lowe |first=Chelsea |date=August 26, 2011 |work=Boston Business Journal |accessdate=30 May 2012}}</ref>


⚫ ==References==
In 2011, the '']'' profiled him as a Champion in Health Care Innovation.<ref name="BBJ">{{cite news |url=http://www.bizjournals.com/boston/print-edition/2011/08/26/champions-in-health-care-jeffrey.html |title=Champions in Health Care: Jeffrey Karp, innovator |last=Lowe |first=Chelsea |date=August 26, 2011 |work=Boston Business Journal |accessdate=30 May 2012}}</ref>
⚫ <references />


==External links==
In 2012, two postdocs from his lab received the prestigious TR35 including Weian Zhao, Bryan Laulicht <ref>http://hst.mit.edu/spotlights/hst-researchers-named-tech-reviews-35-innovators-under-35.</ref>
⚫ * {{cite journal|last1=Sukel|first1=Kayt|title=From porcupine quills to surgical stitches|journal=New Scientist|date=October 2014|volume=224|issue=2990|pages=32–34|doi=10.1016/S0262-4079(14)61953-9|bibcode=2014NewSc.224...32S}}
⚫ *


{{Authority control}}
In 2013, Karp and his collaborator Dr. Bohdan Pomahac were honored with the Innovative Product of the Year Award from the ] (IChemE) for their research on worm-inspired microneedle tissue adhesives

In 2014, Karp successfully pitched a 50K microbiome project at the Brigham and Women's Hospital Shark Tank event that was hosted live in Boston by Kevin O'Leary.<ref>https://www.bostonglobe.com/business/2014/06/04/eight-scientists-emerge-from-brigham-and-women-shark-tank-winners/xMCVwdBvszkgPWonHooZfI/story.html</ref>

In 2014, Maria Nunes Pereira, a graduate student co-advised with Lino Ferreira received the prestigious TR35 <ref>http://www.technologyreview.com/lists/innovators-under-35/2014/inventor/maria-nunes-pereira/</ref>

In 2014, Karp presented a talk at TEDMED that shared unexpected insights into the field of bio-inspiration, the art and science of adapting medical tools, treatments, and technologies from solutions found in nature.<ref>http://www.tedmed.com/speakers/show?id=309656</ref>

In 2015 Karp was recognized by the ]'s top 40 under 40, and received the Kenneth Rainin Foundation's Breakthrough Award.

In 2016, Karp received a Breakthrough award from the Kenneth Rainin Foundation.

In 2017, Karp gave a keynote lecture at the Ontario Hospital Association’s 2017 Health Achieve conference, and was a plenary speaker at the Tissue Engineering Society Europe conference.

In 2017,Boston Magazine recognized Karp as one of 11 Boston Doctors Making Medical Breakthroughs.

==Bibliography==
{{Expand list|date=May 2015}}

===Interviews===
⚫ *{{cite journal |last=Sukel |first=Kayt |authorlink= |authormask= |date=11 October 2014 |title=From porcupine quills to surgical stitches |journal=] |volume=2990 |issue= |pages=32–34 |url= |accessdate= }}
⚫


⚫ ==References==
⚫ <references />


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Latest revision as of 00:11, 18 August 2024

Canadian biomedical engineer
Jeff Karp
Jeffrey Karp
Born1975 (age 49–50)
NationalityCanadian
Alma materMcGill University, University of Toronto, Massachusetts Institute of Technology
Scientific career
FieldsBiomedical engineering
InstitutionsHarvard Medical School, Massachusetts Institute of Technology
Doctoral advisorJohn Davies & Molly Shoichet
Other academic advisorsRobert S. Langer

Jeffrey Karp (born 1975) is a Canadian biomedical engineer working as a Professor of Medicine at Harvard Medical School, Brigham and Women's Hospital, and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the Massachusetts Institute of Technology through the Harvard–MIT Division of Health Sciences and Technology. He is also an affiliate faculty at the Broad Institute.

Education

Karp was born and raised in Peterborough, Ontario. He graduated from McGill University in 1999 with a degree in chemical engineering. While at McGill he also co-founded the McGill Engineering Code of Ethics "The Blueprint".

He received a Ph.D. in Chemical and Biomedical Engineering from the University of Toronto in 2004.

From 2004 until 2006, Karp was a postdoctoral fellow in Robert Langer's laboratory at MIT in the Harvard–MIT Program of Health Sciences and Technology; Karp had applied for the position but Langer had no funds to pay him, so Karp secured funding from the Natural Sciences and Engineering Research Council and Langer accepted him.

Research

In the Langer lab, Karp was inspired by another lab's publication in Nature that described adhesives based on the way that gecko's feet stick to surfaces; he and Langer applied for funding from NSF to make medical adhesives based on geckos, and received the funding.

In 2007 he received an appointment and his own lab at Brigham and Women’s Hospital, at a location near MIT; he retained his association with the Harvard–MIT HST program. He has made mentoring high school students, undergraduates, PhD students, and post docs a priority, and in 2008 he won the Outstanding Undergraduate Student Mentor Award at MIT, and in 2010 he won the Thomas A. McMahon Mentoring Award from the HST program.

In 2013 the company Gecko Biomedical was founded based on the gecko adhesive work, as well as subsequent work done in the Karp lab based on secretions of sandcastle worms.

In 2014 the company Skintifique was formed to commercialize a barrier cream Karp had invented to prevent skin reactions in people with nickel allergy.

In 2015 the company Frequency Therapeutics was founded to create treatments for hearing loss based on work done by Langer and Karp inspired by the ability of some amphibians and birds to regrow hair cells that have been damaged.

In 2016 the company Alivio Therapeutics was founded based on work by Langer and Karp on a hydrogel to deliver drugs, intended to stick to tissue and only release the drug in response to inflammation.

Recognition

Technology Review listed him in 2008 as one of the top innovators under the age of 35 (TR35). Karp received the 2011 Young Investigator award from the Society for Biomaterials, and also in 2011, the Boston Business Journal profiled him as a Champion in Health Care Innovation.

References

  1. Review, MIT Technology. "Innovator Under 35: Jeffrey Karp, 32". MIT Technology Review.
  2. "Parasite inspires new research for Harvard scientist from Peterborough". The Peterborough Examiner. 16 October 2013. Archived from the original on 3 March 2018.
  3. ^ "Alumni". Chemical Engineering. Retrieved 3 March 2018.
  4. "Reporter: The Blueprint". McGill Reporter. 25 February 1999.
  5. "Karp Biosketch". Harvard-MIT Division of Health Sciences and Technology. Archived from the original on 26 June 2009. Retrieved 2 February 2020.
  6. ^ Godfrey, Rena (24 July 2017). "The Bioinspirationalist: Dr. Jeffrey Karp looks to nature to solve big medical issues". Rena Godfrey's Lifestyles Magazine.
  7. ^ Parker, Laura (25 October 2016). "Inspired by nature: the thrilling new science that could transform medicine". The Guardian.
  8. "Prof. Jeff Karp and his gecko-inspired band-aid". MIT Admissions. May 31, 2008.
  9. "Thomas A. McMahon Mentoring Award | Harvard-MIT Health Sciences and Technology". Harvard-MIT HST Program. Archived from the original on 5 March 2016. Retrieved 3 March 2018.
  10. Fischer, S (2014). "At the interface of disciplines: Jeffrey Karp pulls from nature and nano to transform medicine". IEEE Pulse. 5 (2): 30–3. doi:10.1109/MPUL.2013.2296799. PMID 24625588. S2CID 21924036.
  11. "Frequency, Led by MIT's Langer, Aims to Fight Hearing Loss With Drugs". Xconomy. 5 January 2017.
  12. Adams, Ben (May 10, 2016). "Fresh from a new CAR-T biotech, PureTech launches Alivio Therapeutics". FierceBiotech.
  13. "2008 Top 35 Innovators Under 35". Technology Review. 2008. Retrieved August 14, 2011.
  14. "Press Release: Two from Brigham and Women's Hospital Receive Society for Biomaterials Young Investigator Award". Brigham and Women's Hospital. 9 December 2010. Archived from the original on 24 June 2011.
  15. Lowe, Chelsea (August 26, 2011). "Champions in Health Care: Jeffrey Karp, innovator". Boston Business Journal. Retrieved 30 May 2012.

External links

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