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| | verifiedrevid = 265828401 | | verifiedrevid = 265828401 | ||
| | Name = Polyethylene glycol | | Name = Polyethylene glycol | ||
| | ImageFile = |
| ImageFile = Polyethylene glycol.png | ||
| | ImageName = Polyethylene glycol | | ImageName = Polyethylene glycol | ||
| | IUPACName = Polyethylene glycol | | IUPACName = Polyethylene glycol | ||
| | Section1 = {{Chembox Identifiers | | Section1 = {{Chembox Identifiers | ||
| | CASNo_Ref = {{cascite}} | | CASNo_Ref = {{cascite}} | ||
| | CASNo = 25322-68-3 | | CASNo = 25322-68-3 | ||
| }} | }} | ||
| | Section2 = {{Chembox Properties | | Section2 = {{Chembox Properties | ||
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| '''PEG 400''' ( |
'''PEG 400''' (polyethylene glycol 400) is a low molecular weight grade of ]. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations. | ||
| ==Chemical properties== | |||
| ==Additional Properties== | |||
| PEG 400 is strongly ]. The ] of |
PEG 400 is strongly ]. The ] of PEG 400 between hexane and water is 0.000015 (log<math>P = -4.8</math>), indicating that when PEG 400 is mixed with water and hexane, there are only 1.5 parts of PEG 400 in the hexane layer per 100,000 parts of PEG 400 in the water layer.<ref>{{cite journal | ||
| | title= PEG 400, a hydrophilic molecular probe for measuring intestinal permeability | | title= PEG 400, a hydrophilic molecular probe for measuring intestinal permeability | ||
| | author= T. Y. Ma, D. Hollander, P. Krugliak, K. Katz | | author= T. Y. Ma, D. Hollander, P. Krugliak, K. Katz | ||
Revision as of 20:00, 3 June 2010
| |
| Names | |
|---|---|
| IUPAC name Polyethylene glycol | |
| Identifiers | |
| CAS Number | |
| Properties | |
| Chemical formula | C2nH4n+2On+1, n = 8.2 to 9.1 |
| Molar mass | 380-420 g/mol |
| Density | 1.128 g/cm³ |
| Melting point | 4-8 °C |
| Viscosity | 90.0 cSt at 25 °C, 7.3 cSt at 99 °C |
| Hazards | |
| Flash point | 238 °C |
| Lethal dose or concentration (LD, LC): | |
| LD50 (median dose) | 30 mL/kg, orally in rats |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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Infobox references
| |
PEG 400 (polyethylene glycol 400) is a low molecular weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.
Chemical properties
PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log), indicating that when PEG 400 is mixed with water and hexane, there are only 1.5 parts of PEG 400 in the hexane layer per 100,000 parts of PEG 400 in the water layer.
), indicating that when PEG 400 is mixed with water and hexane, there are only 1.5 parts of PEG 400 in the hexane layer per 100,000 parts of PEG 400 in the water layer.
PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.
References
- T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46. PMID 2293598.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
- The Merck Index, 11th Edition
- Handbook of Pharmaceutical Excipients