Polidocanol: Difference between revisions

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	\| KEGG_Ref = {{keggcite\|correct\|kegg}}		\| KEGG_Ref = {{keggcite\|correct\|kegg}}
	\| KEGG = D01993		\| KEGG = D01993
			\| ChEMBL = 1201751
	\| C= 30 \| H= 62 \| O= 10		\| C= 30 \| H= 62 \| O= 10
	\| molecular_weight = ~600 g/mol (average)		\| molecular_weight = ~600 g/mol (average)

Revision as of 13:05, 19 May 2011

Pharmaceutical compound

Polidocanol
Clinical data

Other names	Polydocanol Laureth 9 Macrogol lauryl ether Lauromacrogol PEG-9 lauryl alcohol POE-9 lauryl alcohol Dodecylpolyethyleneglycolether Hydroxyl polyethoxy dodecane Oxypolyethoxydodecane
Pregnancy category	Topical: allowed Injection: contraindication in months 1–3 and after week 36
ATC code	C05BB02 (WHO)
Legal status
Legal status	OTC (topical), ℞ (injection)
Identifiers
CAS Number	9002-92-0 3055-99-0 (with nine ethyleneglycol units)
PubChem CID	656641
KEGG	D01993
ChEMBL	ChEMBL1201751
CompTox Dashboard (EPA)	DTXSID5039721
ECHA InfoCard	100.019.351
Chemical and physical data
Formula	C₃₀H₆₂O₁₀
Molar mass	~600 g/mol (average) g·mol
(verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused for example by dry skin conditions such as eczema.

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera and Aethoxysklerol. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.

References

"E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
Facts and Companies: Varicose Vein Treatment Approved
"Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.

Vasoprotectives (C05)

Antihemorrhoidals for topical use

corticosteroids	Hydrocortisone Prednisolone Betamethasone Fluorometholone Fluocortolone Dexamethasone Fluocinolone acetonide Fluocinonide
local anesthetics	Lidocaine Tetracaine Benzocaine Dibucaine Procaine Oxetacaine Pramocaine
other	Tribenoside

Antivaricose therapy

heparins or heparinoids for topical use	Organo-heparinoid Sodium apolate Heparin Pentosan polysulfate
sclerosing agents for local injection	Monoethanolamine oleate Polidocanol Inverted sugar syrup Sodium tetradecyl sulfate Phenol
other	Calcium dobesilate

Capillary stabilising agents

bioflavonoids	Rutoside Monoxerutin Diosmin Troxerutin Hidrosmin
other	Tribenoside Etamsylate

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