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'''U46619''' is a stable synthetic ] of the ] PGH<sub>2</sub> first prepared in 1975.<ref>{{cite journal | author = Bundy, G. L. | title = Synthesis of prostaglandin endoperoxide analogs | journal = Tetrahedron Letters | year = 1975 | volume = 24 | pages = 1957–1960 | doi = 10.1016/S0040-4039(00)72333-1}}</ref> U46619 is a ] that mimics the hydroosmotic effect of ].<ref>{{cite journal | title = Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport | author = Burch, Ronald M.; Halushka, Perry V. | journal = Journal of Pharmacology and Experimental Therapeutics |year=1983|volume =224|issue=1|pages= 108–17 | pmid = 6294273}}</ref> It also mimics the effects of ] by activating ].<ref>{{cite journal | title = Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP | author = Rittenhouse, Susan E. | journal = Biochemical Journal |year=1984 | volume = 222 | issue = 1 | pages = 103–110 | pmid = 6433894 | pmc = 1144149}}</ref><ref>{{cite journal|title=Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697|author=Michael P. Walsh, et all|url=http://biosupport.licor.com/docs/2005/BJ20050237.pdf}}</ref> '''U46619''' is a stable synthetic ] of the ] PGH<sub>2</sub> first prepared in 1975.<ref>{{cite journal | author = Bundy, G. L. | title = Synthesis of prostaglandin endoperoxide analogs | journal = Tetrahedron Letters | year = 1975 | volume = 24 | pages = 1957–1960 | doi = 10.1016/S0040-4039(00)72333-1 | issue = 24}}</ref> U46619 is a ] that mimics the hydroosmotic effect of ].<ref>{{cite journal | title = Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport | author = Burch, Ronald M.; Halushka, Perry V. | journal = Journal of Pharmacology and Experimental Therapeutics |year=1983|volume =224|issue=1|pages= 108–17 | pmid = 6294273}}</ref> It also mimics the effects of ] by activating ].<ref>{{cite journal | title = Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP | author = Rittenhouse, Susan E. | journal = Biochemical Journal |year=1984 | volume = 222 | issue = 1 | pages = 103–110 | pmid = 6433894 | pmc = 1144149}}</ref><ref>{{cite journal|title=Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697|author=Michael P. Walsh, et all|url=http://biosupport.licor.com/docs/2005/BJ20050237.pdf}}</ref>


==References== ==References==

Revision as of 22:06, 13 October 2011

U46619
Names
IUPAC name (Z)-7--3-oxabicycloheptan-6-yl]hept-5-enoic acid
Identifiers
CAS Number
3D model (JSmol)
ECHA InfoCard 100.164.944 Edit this at Wikidata
IUPHAR/BPS
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • CCCCC(O)/C=C/12OC(C2)1C/C=C\CCCC(O)=O
Properties
Chemical formula C21H34O4
Molar mass 350.49 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

U46619 is a stable synthetic analog of the prostaglandin PGH2 first prepared in 1975. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin. It also mimics the effects of thromboxane by activating phospholipase C.

References

  1. Bundy, G. L. (1975). "Synthesis of prostaglandin endoperoxide analogs". Tetrahedron Letters. 24 (24): 1957–1960. doi:10.1016/S0040-4039(00)72333-1.
  2. Burch, Ronald M.; Halushka, Perry V. (1983). "Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport". Journal of Pharmacology and Experimental Therapeutics. 224 (1): 108–17. PMID 6294273.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. Rittenhouse, Susan E. (1984). "Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP". Biochemical Journal. 222 (1): 103–110. PMC 1144149. PMID 6433894.
  4. Michael P. Walsh, et all. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). {{cite journal}}: Cite journal requires |journal= (help)
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