Tacalcitol: Difference between revisions

Revision as of 01:44, 1 July 2011 editPeryeat (talk \| contribs)Extended confirmed users2,689 editsNo edit summary← Previous edit		Revision as of 02:55, 1 July 2011 edit undoCheMoBot (talk \| contribs)Bots141,565 edits Updating {{drugbox}} (changes to verified fields - updated 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WiNext edit →
Line 1:		Line 1:
	{{drugbox		{{drugbox
			\| Verifiedfields = changed
	\| UNII_Ref = {{fdacite\|~~correct~~\|FDA}}		\| UNII_Ref = {{fdacite\|changed\|FDA}}
	\| UNII = C2W72OJ5ZU		\| UNII = C2W72OJ5ZU
	\| verifiedrevid = 376121485		\| verifiedrevid = 376121485

Revision as of 02:55, 1 July 2011

Pharmaceutical compound

Tacalcitol
Clinical data
Other names	(1R,3S,5Z)-5--7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Routes of administration	Topical
ATC code	D05AX04 (WHO)
Identifiers
IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
CAS Number	57333-96-7
PubChem CID	5283734
UNII	C2W72OJ5ZU
CompTox Dashboard (EPA)	DTXSID90905111
ECHA InfoCard	100.220.855
Chemical and physical data
Formula	C₂₇H₄₄O₃
Molar mass	416.64 g·mol
(what is this?) (verify)

Tacalcitol is a synthetic vitamin D₃ analogue.

Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

Tacalcitol exerts its biological activity by preventing the proliferation of keratinocytes.

It is used to treat psoriasis.

Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes". Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. PMID 11464105.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (2006). "Tacalcitol and narrow-band phototherapy in patients with vitiligo". Clin. Exp. Dermatol. 31 (2): 200–5. doi:10.1111/j.1365-2230.2005.02037.x. PMID 16487090. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (1998). "1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro". Br. J. Dermatol. 139 (5): 897–901. doi:10.1046/j.1365-2133.1998.02522.x. PMID 9892963. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Topical

Tars	Tar / Coal tar
Antracens	Dithranol
Psoralens	Trioxysalen Methoxsalen
Other	Fumaric acid vitamin D (Calcipotriol Calcipotriol/betamethasone Calcitriol Tacalcitol) Tazarotene

Systemic

Psoralens	Trioxysalen Methoxsalen Bergapten
Retinoids	Etretinate Acitretin

This dermatologic drug article is a stub. You can help Misplaced Pages by expanding it.