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'''Aphidicolin''' is defined as a tetracyclic ] ] with antiviral and antimitotical properties. Aphidicolin is a reversible ] of ] nuclear ] replication. It blocks the cell cycle at early ]. It is a specific inhibitor of ] B,D in eukaryotic cells and in some viruses and an ] inducer in ] cells. '''Aphidicolin''' is defined as a tetracyclic ] ] with antiviral and antimitotical properties. Aphidicolin is a reversible ] of ] nuclear ] replication. It blocks the cell cycle at early ]. It is a specific inhibitor of ] A,D in eukaryotic cells and in some viruses and an ] inducer in ] cells.
<br>Natural aphidicolin is a secondary metabolite of the fungus '']''<ref> from ]</ref>. <br>Natural aphidicolin is a secondary metabolite of the fungus '']''<ref> from ]</ref>.


Revision as of 15:57, 28 July 2011

Aphidicolin
Names
IUPAC name (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocycloheptanaphthalene-3,9-diol
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.109.656 Edit this at Wikidata
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1Key: NOFOAYPPHIUXJR-APNQCZIXSA-N
  • InChI=1/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1Key: NOFOAYPPHIUXJR-APNQCZIXBU
SMILES
  • OC4(O)CC31C4C3CC2(C)(CO)(O)CC12C
Properties
Chemical formula C20H34O4
Molar mass 338.48 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an apoptosis inducer in HeLa cells.
Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.

References

  • Dhillon VS, Husain SA, Ray GN (2003). "Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients". Teratog., Carcinog. Mutagen. Suppl 1: 35–45. doi:10.1002/tcm.10068. PMID 12616595.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  1. Aphidicolin product page from Fermentek


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