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'''Inositol pentakisphosphate''' (abbreviated '''IP5''') is a molecule derived from ] by adding a ] with the help of ] (IPMK). It is believed to be one of the many ]s in the ] family. It "is implicated in a wide array of biological and pathophysiological responses, including tumorigenesis, invasion and metastasis, therefore specific inhibitors of the kinase may prove useful in cancer therapy."<ref name= "IP Promotes apoptosis">{{cite journal | pmid=14755253 | year=2004 | last1=Piccolo | first1=E. | last2=Vignati | first2=S. | last3=Maffucci | first3=T. | last4=Innominato | first4=P. F. | last5=Riley | first5=A. M. | last6=Potter | first6=B. V. | last7=Pandolfi | first7=P. P. | last8=Broggini | first8=M. | last9=Iacobelli | first9=S. | title=Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway | volume=23 | issue=9 | pages=1754–1765 | doi=10.1038/sj.onc.1207296 | journal=]}}</ref> '''Inositol pentakisphosphate''' (abbreviated '''IP5''') is a molecule derived from ] by adding a ] with the help of ] (IPMK). It is believed to be one of the many ]s in the ] family. It "is implicated in a wide array of biological and pathophysiological responses, including tumorigenesis, invasion and metastasis, therefore specific inhibitors of the kinase may prove useful in cancer therapy."<ref name= "IP Promotes apoptosis">{{cite journal | pmid=14755253 | year=2004 | last1=Piccolo | first1=E. | last2=Vignati | first2=S. | last3=Maffucci | first3=T. | last4=Innominato | first4=P. F. | last5=Riley | first5=A. M. | last6=Potter | first6=B. V. | last7=Pandolfi | first7=P. P. | last8=Broggini | first8=M. | last9=Iacobelli | first9=S. | title=Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway | volume=23 | issue=9 | pages=1754–1765 | doi=10.1038/sj.onc.1207296 | journal=]}}</ref>


IP5 also plays a role in defense signaling in plants. It potentiates the interaction of the plant hormone ] by its receptor.<ref>{{cite journal |last=Sheard |first=L. B. |year=2010 |title=Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor|journal=] |volume=468 |pages=400–405 |doi=10.1038/nature09430 |pmid=20927106 |pmc=2988090 |issue=7322}}</ref><ref>{{cite journal |last=Mosblech |first=A. |year=2010 |title=Jasmonic acid perception by COI1 involves inositol polyphosphates in ''Arabidopsis thaliana'' |journal=] | volume=65 |issue=6 |pages=949–957 |doi=10.1111/j.1365-313X.2011.04480.x |pmid=21205029}}</ref> IP5 also plays a role in defense signaling in plants. It potentiates the interaction of the plant hormone ] by its receptor.<ref>{{cite journal |last=Sheard |first=L. B. |year=2010 |title=Jasmonate perception by inositol phosphate-potentiated COI1-JAZ co-receptor|journal=] |volume=468 |pages=400–405 |doi=10.1038/nature09430 |pmid=20927106 |pmc=2988090 |issue=7322 |last2=Tan |first2=Xu |last3=Mao |first3=Haibin |last4=Withers |first4=John |last5=Ben-Nissan |first5=Gili |last6=Hinds |first6=Thomas R. |last7=Kobayashi |first7=Yuichi |last8=Hsu |first8=Fong-Fu |last9=Sharon |first9=Michal}}</ref><ref>{{cite journal |last=Mosblech |first=A. |year=2010 |title=Jasmonic acid perception by COI1 involves inositol polyphosphates in ''Arabidopsis thaliana'' |journal=] | volume=65 |issue=6 |pages=949–957 |doi=10.1111/j.1365-313X.2011.04480.x |pmid=21205029 |last2=Thurow |first2=Corinna |last3=Gatz |first3=Christiane |last4=Feussner |first4=Ivo |last5=Heilmann |first5=Ingo}}</ref>


==References== ==References==

Revision as of 13:59, 4 October 2011

myo-Inositol 1,3,4,5,6-pentakisphosphate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
InChI
  • InChI=1S/C6H17O21P5/c7-1-2(23-28(8,9)10)4(25-30(14,15)16)6(27-32(20,21)22)5(26-31(17,18)19)3(1)24-29(11,12)13/h1-7H,(H2,8,9,10)(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)(H2,20,21,22)/p-10/t1-,2+,3-,4-,5+,6+Key: CTPQAXVNYGZUAJ-KXXVROSKSA-D
  • InChI=1/C6H17O21P5/c7-1-2(23-28(8,9)10)4(25-30(14,15)16)6(27-32(20,21)22)5(26-31(17,18)19)3(1)24-29(11,12)13/h1-7H,(H2,8,9,10)(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)(H2,20,21,22)/p-10/t1-,2+,3-,4-,5+,6+Key: CTPQAXVNYGZUAJ-JSZKNSOJBF
SMILES
  • O=P()()O1(OP()()=O)(OP()()=O)(O)(OP()()=O)1OP()()=O
Properties
Chemical formula C6H17O21P5
Molar mass 580.050 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Inositol pentakisphosphate (abbreviated IP5) is a molecule derived from inositol tetrakisphosphate by adding a phosphate group with the help of inositol polyphosphate multikinase (IPMK). It is believed to be one of the many second messengers in the inositol phosphate family. It "is implicated in a wide array of biological and pathophysiological responses, including tumorigenesis, invasion and metastasis, therefore specific inhibitors of the kinase may prove useful in cancer therapy."

IP5 also plays a role in defense signaling in plants. It potentiates the interaction of the plant hormone JA-Ile by its receptor.

References

  1. Sigma Aldrich
  2. Piccolo, E.; Vignati, S.; Maffucci, T.; Innominato, P. F.; Riley, A. M.; Potter, B. V.; Pandolfi, P. P.; Broggini, M.; Iacobelli, S. (2004). "Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway". Oncogene. 23 (9): 1754–1765. doi:10.1038/sj.onc.1207296. PMID 14755253.
  3. Sheard, L. B.; Tan, Xu; Mao, Haibin; Withers, John; Ben-Nissan, Gili; Hinds, Thomas R.; Kobayashi, Yuichi; Hsu, Fong-Fu; Sharon, Michal (2010). "Jasmonate perception by inositol phosphate-potentiated COI1-JAZ co-receptor". Nature. 468 (7322): 400–405. doi:10.1038/nature09430. PMC 2988090. PMID 20927106.
  4. Mosblech, A.; Thurow, Corinna; Gatz, Christiane; Feussner, Ivo; Heilmann, Ingo (2010). "Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana". The Plant Journal. 65 (6): 949–957. doi:10.1111/j.1365-313X.2011.04480.x. PMID 21205029.


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