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Cholera vaccine is a vaccine used against cholera.

It is largely used by backpackers and persons visiting locations where there is a high risk of cholera infection. However, it does not provide 100% immunity from the disease, and food hygiene precautions should also be taken into consideration when visiting an area where there is a high risk of becoming infected with cholera.

A cholera vaccine is currently used in Vietnam.

Cholera vaccine for travellers is available in Italy, but not in France.

Although the protection observed has been described as "moderate", herd immunity can multiply the effectiveness of vaccination. Although the vaccine can be dangerous for children, administration of the vaccine to adults can confer protection to children indirectly.

A drinkable cholera vaccine, dukoral(The vaccine contains killed whole V. cholerae O1 bacteria and the recombinant non-toxic B-subunit of the cholera toxin (CTB). Bacterial strains of both Inaba and Ogawa serotypes and of El Tor and Classical biotypes are included in the vaccine. DUKORAL is taken orally with bicarbonate buffer, which protects the antigens from the gastric acid. The vaccine acts by inducing antibodies against both the bacterial components and CTB. The antibacterial intestinal antibodies prevent the bacteria from attaching to the intestinal wall thereby impeding colonisation of V. cholerae O1. The anti-toxin intestinal antibodies prevent the cholera toxin from binding to the intestinal mucosal surface thereby preventing the toxin-mediated diarrhoeal symptoms.)), also protects against traveler's diarrhea.

References

1. Mahalanabis D, Lopez AL, Sur D; et al. (2008). "A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India". PLoS ONE. 3 (6): e2323. doi:10.1371/journal.pone.0002323. PMC 2396289. PMID 18523643. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
2. Cholera+vaccines at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
3. Anh DD, Canh do G, Lopez AL; et al. (2007). "Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults". Vaccine. 25 (6): 1149–55. doi:10.1016/j.vaccine.2006.09.049. PMID 17055622. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
4. Ali M, Emch M, von Seidlein L; et al. (2005). "Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis". Lancet. 366 (9479): 44–9. doi:10.1016/S0140-6736(05)66550-6. PMID 15993232. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
5. Ali M, Emch M, Yunus M; et al. (2008). "Vaccine Protection of Bangladeshi infants and young children against cholera: implications for vaccine deployment and person-to-person transmission". Pediatr. Infect. Dis. J. 27 (1): 33–7. doi:10.1097/INF.0b013e318149dffd. PMID 18162935. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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