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'''Trolox''' is ]'s trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a water-soluble derivative of ]. It is an ], like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage. '''Trolox''' is ]'s trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a lipo-soluble derivative of ]. It is an ], like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage.


] (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ] decolorization assay.<ref>Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237</ref> Other measures include ] (ORAC) and ] (FRAP). ] (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ] decolorization assay.<ref>Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237</ref> Other measures include ] (ORAC) and ] (FRAP).

Revision as of 12:23, 12 January 2012

Trolox
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ECHA InfoCard 100.053.094 Edit this at Wikidata
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O
Properties
Chemical formula C14H18O4
Molar mass 250.294 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Trolox is Hoffman-LaRoche's trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a lipo-soluble derivative of vitamin E. It is an antioxidant, like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage.

Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ABTS decolorization assay. Other measures include oxygen radical absorbance capacity (ORAC) and ferric reducing ability of plasma (FRAP).

Notes

  1. Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237
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