Idursulfase: Difference between revisions

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Revision as of 09:43, 1 November 2011

Pharmaceutical compound

Idursulfase (brand name Elaprase) is a drug used to treat Hunter syndrome (also called Mucopolysaccharoidosis II). It is a purified form of the lysosomal enzyme iduronate-2-sulfatase and is produced by recombinant DNA technology in a human cell line.

It is one of the most expensive drugs ever produced, costing $375,000 per year.

"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC (2007). "Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II". Mol. Genet. Metab. 91 (2): 183–90. doi:10.1016/j.ymgme.2007.03.003. PMID 17459751.{{cite journal}}: CS1 maint: multiple names: authors list (link)
"Drug approved to treat rare but potentially deadly disease". Retrieved 2011-04-29.
Health Care: The World's Most Expensive Drugs, Matthew Herper, Forbes, Feb. 22, 2010

idursulfase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Other alimentary tract and metabolism products (A16)
Amino acids and derivatives	Ademetionine Betaine Carglumic acid Glutamine Levocarnitine Mercaptamine Metreleptin
Enzymes	Amino acids: phenylalanine ammonia-lyase (Pegvaliase) Carbohydrate metabolism: sucrase (Sacrosidase) alpha-glucosidase (Alglucosidase alfa, Avalglucosidase alfa, Cipaglucosidase alfa) Glycolipid/sphingolipid: glucocerebrosidase (Alglucerase Imiglucerase Taliglucerase alfa Velaglucerase alfa) alpha-galactosidase (Agalsidase alfa Agalsidase beta Pegunigalsidase alfa) Glycosaminoglycan: iduronidase (Laronidase) arylsulfatase B (Galsulfase) iduronate-2-sulfatase (Idursulfase) idursulfase beta Lipid: lysosomal lipase (Sebelipase alfa) Phosphate: Asfotase alfa atidarsagene autotemcel cerliponase alfa eladocagene exuparvovec elosulfase alfa olipudase alfa pabinafusp alfa pegzilarginase vestronidase alfa
Other	Anethole trithione Eliglustat Givosiran Glycerol phenylbutyrate Leriglitazone Lumasiran Miglustat Nedosiran Nitisinone Sapropterin Sepiapterin Sodium benzoate (+sodium phenylacetate) Sodium phenylbutyrate Teduglutide Trientine Tioctic acid Triheptanoin Uridine triacetate Velmanase alfa Zinc acetate

Amino acids and derivatives

Other

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