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Revision as of 12:46, 20 November 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'CASNo_Ref') per Chem/Drugbox validation (report ...← Previous edit Revision as of 16:52, 5 March 2012 edit undo130.60.152.125 (talk) added the name-giving frog speciesNext edit →
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'''Bombesin''' is a 14-] ]<ref name="pmid18185064">{{cite journal | author = Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT | title = Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states | journal = Current Opinion in Endocrinology, Diabetes, and Obesity | volume = 15 | issue = 1 | pages = 58–64 | year = 2008 | month = February | pmid = 18185064 | pmc = 2631407 | doi = 10.1097/MED.0b013e3282f3709b | url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1752-296X&volume=15&issue=1&spage=58}}</ref> originally isolated from the ] of a ]. It has two known ] in ] called ] and ]. It stimulates ] release from ]. It activates three different ]-coupled ] known as BBR1, -2, and -3.<ref name="pmid19115523">{{cite journal | author = Weber HC | title = Regulation and signaling of human bombesin receptors and their biological effects | journal = Current Opinion in Endocrinology, Diabetes, and Obesity | volume = 16 | issue = 1 | pages = 66–71 | year = 2009 | month = February | pmid = 19115523 | doi = | url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1752-296X&volume=16&issue=1&spage=66}}</ref> It also activates these receptors in the ]. Together with ], it is the second major source of ] signals that stop eating behaviour.<ref name="pmid11127929">{{cite journal | author = Yamada K, Wada E, Wada K | title = Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice | journal = Annals of Medicine | volume = 32 | issue = 8 | pages = 519–29 | year = 2000 | month = November | pmid = 11127929 | doi = | url = }}</ref> '''Bombesin''' is a 14-] ]<ref name="pmid18185064">{{cite journal | author = Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT | title = Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states | journal = Current Opinion in Endocrinology, Diabetes, and Obesity | volume = 15 | issue = 1 | pages = 58–64 | year = 2008 | month = February | pmid = 18185064 | pmc = 2631407 | doi = 10.1097/MED.0b013e3282f3709b | url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1752-296X&volume=15&issue=1&spage=58}}</ref> originally isolated from the ] of the ] (''Bombina orientalis''). It has two known ] in ] called ] and ]. It stimulates ] release from ]. It activates three different ]-coupled ] known as BBR1, -2, and -3.<ref name="pmid19115523">{{cite journal | author = Weber HC | title = Regulation and signaling of human bombesin receptors and their biological effects | journal = Current Opinion in Endocrinology, Diabetes, and Obesity | volume = 16 | issue = 1 | pages = 66–71 | year = 2009 | month = February | pmid = 19115523 | doi = | url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1752-296X&volume=16&issue=1&spage=66}}</ref> It also activates these receptors in the ]. Together with ], it is the second major source of ] signals that stop eating behaviour.<ref name="pmid11127929">{{cite journal | author = Yamada K, Wada E, Wada K | title = Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice | journal = Annals of Medicine | volume = 32 | issue = 8 | pages = 519–29 | year = 2000 | month = November | pmid = 11127929 | doi = | url = }}</ref>


Bombesin is also a ] marker for small cell carcinoma of lung, gastric cancer, and neuroblastoma.<ref name="pmid10636070">{{cite journal | author = Ohlsson B, Fredäng N, Axelson J | title = The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines | journal = Scandinavian Journal of Gastroenterology | volume = 34 | issue = 12 | pages = 1224–9 | year = 1999 | month = December | pmid = 10636070 | doi = | url = }}</ref> Bombesin is also a ] marker for small cell carcinoma of lung, gastric cancer, and neuroblastoma.<ref name="pmid10636070">{{cite journal | author = Ohlsson B, Fredäng N, Axelson J | title = The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines | journal = Scandinavian Journal of Gastroenterology | volume = 34 | issue = 12 | pages = 1224–9 | year = 1999 | month = December | pmid = 10636070 | doi = | url = }}</ref>

Revision as of 16:52, 5 March 2012

Bombesin
File:Bombesin full.png
Names
Other names Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
IUPHAR/BPS
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)80-31-56(100)87-51(29-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-50(27-39-26-38-12-9-10-13-41(38)84-39)66(109)83-37(7)60(103)95-58(36(5)6)70(113)81-32-57(101)86-49(28-40-30-78-33-82-40)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,26,30,33-37,42-51,58,84H,11,14-25,27-29,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,82)(H,80,104)(H,81,113)(H,83,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1Key: DNDCVAGJPBKION-DOPDSADYSA-N
  • InChI=1/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)80-31-56(100)87-51(29-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-50(27-39-26-38-12-9-10-13-41(38)84-39)66(109)83-37(7)60(103)95-58(36(5)6)70(113)81-32-57(101)86-49(28-40-30-78-33-82-40)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,26,30,33-37,42-51,58,84H,11,14-25,27-29,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,82)(H,80,104)(H,81,113)(H,83,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1Key: DNDCVAGJPBKION-DOPDSADYBW
SMILES
  • C(C(=O)N(C(C)C)C(=O)NCC(=O)N(Cc1cnc1)C(=O)N(CC(C)C)C(=O)N(CCSC)C(=O)N)NC(=O)(Cc2cc3ccccc32)NC(=O)(CCC(=O)N)NC(=O)(CC(=O)N)NC(=O)CNC(=O)(CC(C)C)NC(=O)(CCCNC(=N)N)NC(=O)(CCC(=O)N)NC(=O)4CCC(=O)N4
Properties
Chemical formula C71H110N24O18S
Molar mass 1619.85
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Bombesin is a 14-amino acid peptide originally isolated from the skin of the oriental fire-bellied toad (Bombina orientalis). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.

Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, and neuroblastoma.

See also

References

  1. Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT (2008). "Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states". Current Opinion in Endocrinology, Diabetes, and Obesity. 15 (1): 58–64. doi:10.1097/MED.0b013e3282f3709b. PMC 2631407. PMID 18185064. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. Weber HC (2009). "Regulation and signaling of human bombesin receptors and their biological effects". Current Opinion in Endocrinology, Diabetes, and Obesity. 16 (1): 66–71. PMID 19115523. {{cite journal}}: Unknown parameter |month= ignored (help)
  3. Yamada K, Wada E, Wada K (2000). "Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice". Annals of Medicine. 32 (8): 519–29. PMID 11127929. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. Ohlsson B, Fredäng N, Axelson J (1999). "The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology. 34 (12): 1224–9. PMID 10636070. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
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