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Revision as of 14:38, 24 November 2011 editBeetstra (talk \| contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456763669 of page Olsalazine for the Chem/Drugbox validation project (updated: 'ChEMBL', 'KEGG').← Previous edit		Revision as of 14:39, 24 November 2011 edit undoBeetstra (talk \| contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456966867 of page Omeprazole for the Chem/Drugbox validation project (updated: 'DrugBank').Next edit →
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	{{ambox \| text = This page contains a copy of the infobox ({{tl\|drugbox}}) taken from revid of page ] with values updated to verified values.}}		{{ambox \| text = This page contains a copy of the infobox ({{tl\|drugbox}}) taken from revid of page ] with values updated to verified values.}}
	{{Drugbox		{{Drugbox\| Verifiedfields = changed
		⚫	\| verifiedrevid = 419941151
	\| Verifiedfields = changed
			\| drug_name = Omeprazole
⚫	\| verifiedrevid = ~~402512533~~
	\| IUPAC_name = 5--2-~~hydroxybenzoic acid~~		\|IUPAC_name = (''RS'')-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1''H''-benzoimidazole
	\| image = ~~Olsalazine~~.~~png~~		\| image = Omeprazole.svg
			\| imagename = 1 : 1 mixture (racemate)

			\| width=220
	<!--Clinical data-->
			\| image2 = Omeprazole_3d_structure.png
	\| tradename = Dipentum
			\| width = 220
	\| Drugs.com = {{drugs.com\|monograph\|dipentum}}
	\| MedlinePlus = a601088
	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
	\| pregnancy_US = C<!-- A / B / C / D / X -->
	\| pregnancy_category =
	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
	\| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
	\| legal_US = Rx-only<!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
	\| legal_status =
⚫	\| routes_of_administration =

	<!--Pharmacokinetic data-->
	\| bioavailability =
⚫	\| protein_bound = 99%
	\| metabolism =
⚫	\| elimination_half-life = 0.9 hours
	\| excretion =

	<!--Identifiers-->
	\| CASNo_Ref = {{cascite\|correct\|CAS}}		\| CASNo_Ref = {{cascite\|correct\|CAS}}
⚫	\| CAS_number_Ref = {{cascite\|correct\|??}}
⚫	\| CAS_number = ~~15722~~-48-2
⚫	\| ATC_prefix = ~~A07~~
⚫	\| ATC_suffix = ~~EC03~~
⚫	\| PubChem = ~~6003770~~
⚫	\| DrugBank_Ref = {{drugbankcite\|~~changed~~\|drugbank}}
⚫	\| DrugBank = ~~DB01250~~
⚫	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
⚫	\| ChemSpiderID = ~~10642377~~
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = ~~ULS5I8J03O~~		\| UNII = KG60484QX9
	\| KEGG_Ref = {{keggcite\|~~changed~~\|kegg}}		\| KEGG_Ref = {{keggcite\|correct\|kegg}}
	\| KEGG = ~~<!-- blanked - oldvalue: D00727 -->~~		\| KEGG = D00455
			\| InChI = 1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
⚫	\| ChEMBL_Ref = {{ebicite\|~~changed~~\|EBI}}
			\| InChIKey = SUBDBMMJDZJVOS-UHFFFAOYAZ
	\| ChEMBL = <!-- blanked - oldvalue: 571540 -->
		⚫	\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}
	\| chemical_formula =
			\| ChEMBL = 1503
⚫	\| C=14 \| H=10 \| N=2 \| O=6
⚫	\| molecular_weight = ~~302~~.~~239g~~/mol
	\| smiles = O=C(O)c1cc(ccc1O)/N=N/c2cc(C(O)=O)c(O)cc2
	\| InChI = 1/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+
	\| InChIKey = QQBDLJCYGRGAKP-FOCLMDBBBJ
	\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChI = 1S/~~C14H10N2O6~~/~~c17~~-11-3-1-7(~~5-9~~(11)13(19)20)15-16-8-2-4-12(18)~~10(6~~-8)14(21)22/h1-6,17-~~18H~~,(H,19,20)~~(H,21,22)/b16-15+~~		\| StdInChI = 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
	\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChIKey = ~~QQBDLJCYGRGAKP~~-~~FOCLMDBBSA~~-N		\| StdInChIKey = SUBDBMMJDZJVOS-UHFFFAOYSA-N
		⚫	\| CAS_number_Ref = {{cascite\|correct\|??}}
		⚫	\| CAS_number=73590-58-6
		⚫	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
		⚫	\| ChemSpiderID = 4433
		⚫	\| ATC_prefix=A02
		⚫	\| ATC_suffix=BC01
			\| ATC_supplemental=
			\| ChEBI_Ref = {{ebicite\|changed\|EBI}}
			\| ChEBI = 7772
		⚫	\| PubChem=4594
		⚫	\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
		⚫	\| DrugBank = DB00338
		⚫	\| C = 17 \| H = 19 \| N = 3 \| O = 3 \| S = 1
		⚫	\| molecular_weight = 345.4 g/mol
			\| smiles = O=S(c2nc1ccc(OC)cc1n2)Cc3ncc(c(OC)c3C)C
			\| bioavailability= 35–76%<ref>. AstraZeneca Pharmaceuticals.</ref><ref>{{cite journal
			\| last1 = Vaz-Da-Silva \| first1 = M
			\| last2 = Loureiro \| first2 = AI
			\| last3 = Nunes \| first3 = T
			\| last4 = Maia \| first4 = J
			\| last5 = Tavares \| first5 = S
			\| last6 = Falcão \| first6 = A
			\| last7 = Silveira \| first7 = P
			\| last8 = Almeida \| first8 = L
			\| last9 = Soares-Da-Silva \| first9 = P
			\| title = Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions
			\| journal = ]
			\| volume = 25
			\| issue = 6
			\| pages = 391–9
			\| year = 2005
			\| pmid = 17532679
			\| url = http://www.medscape.com/viewarticle/508018
			\| doi = 10.2165/00044011-200525060-00004
			}}</ref>
		⚫	\| protein_bound = 95%
			\| metabolism = ] (], ])
		⚫	\| elimination_half-life= 1 – 1.2 hours
			\| excretion = 80% ]<br>20% ]
			\| pregnancy_US = C
			\| pregnancy_AU = B3
			\| legal_AU = S4
			\| legal_UK = POM
			\| legal_US = OTC
		⚫	\| routes_of_administration= Oral, ]
			\| licence_US = Omeprazole
	}}		}}

Revision as of 14:39, 24 November 2011

This page contains a copy of the infobox ({{drugbox}}) taken from revid 456966867 of page Omeprazole with values updated to verified values.

Omeprazole
Clinical data


License data	US FDA: Omeprazole
Pregnancy category	AU: B3
Routes of administration	Oral, IV
ATC code	A02BC01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: OTC
Pharmacokinetic data
Bioavailability	35–76%
Protein binding	95%
Metabolism	Hepatic (CYP2C19, CYP3A4)
Elimination half-life	1 – 1.2 hours
Excretion	80% Renal 20% Faecal
Identifiers
IUPAC name (RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzoimidazole
CAS Number	73590-58-6
PubChem CID	4594
DrugBank	DB00338
ChemSpider	4433
UNII	KG60484QX9
KEGG	D00455
ChEBI	CHEBI:7772
ChEMBL	ChEMBL1503
Chemical and physical data
Formula	C₁₇H₁₉N₃O₃S
Molar mass	345.4 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=S(c2nc1ccc(OC)cc1n2)Cc3ncc(c(OC)c3C)C
InChI InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20) Key:SUBDBMMJDZJVOS-UHFFFAOYSA-N
(what is this?) (verify)

Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.
Vaz-Da-Silva, M; Loureiro, AI; Nunes, T; Maia, J; Tavares, S; Falcão, A; Silveira, P; Almeida, L; Soares-Da-Silva, P (2005). "Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions". Clin Drug Investig. 25 (6): 391–9. doi:10.2165/00044011-200525060-00004. PMID 17532679.