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Revision as of 15:56, 24 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 400843689 of page Paxilline for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CASNo').← Previous edit Revision as of 15:57, 24 November 2011 edit undoBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 447772444 of page Pazopanib for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').Next edit →
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} {{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{chembox {{Drugbox
| IUPAC_name = <nowiki>5--2-pyrimidinyl]amino]-2-methylbenzolsulfonamide</nowiki>
| verifiedrevid = 400842436
| image = Pazopanib structure.svg
|ImageFile=Paxilline.png

|ImageSize=200px
<!--Clinical data-->
|IUPACName= (2''R'',&#x200b;4b''S'',&#x200b;6a''S'',&#x200b;12b''S'',&#x200b;12c''R'',&#x200b;14a''S'')-&#x200b;4b-&#x200b;hydroxy-&#x200b;2-&#x200b;(1-&#x200b;hydroxy-&#x200b;1-&#x200b;methylethyl)-&#x200b;12b,&#x200b;12c-&#x200b;dimethyl-&#x200b;5,&#x200b;6,&#x200b;6a,&#x200b;7,&#x200b;12,&#x200b;12b,&#x200b;12c,&#x200b;13,&#x200b;14,&#x200b;14a-&#x200b;decahydro-&#x200b;2''H''-&#x200b;chromeno&#x200b;&#x200b;indeno&#x200b;&#x200b;indol-&#x200b;3(4b''H'')-&#x200b;one
| tradename =
|OtherNames=
| Drugs.com = {{drugs.com|monograph|pazopanib-hydrochloride}}
|Section1={{Chembox Identifiers
| MedlinePlus = a610013
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| licence_EU = Votrient
⚫ | ChemSpiderID = 94753
| licence_US = Pazopanib
| InChI = 1/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| InChIKey = ACNHBCIZLNNLRS-UBGQALKQBX
| pregnancy_US = D
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_category =
| StdInChI = 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | StdInChIKey = ACNHBCIZLNNLRS-UBGQALKQSA-N
| CASNo = <!-- blanked - oldvalue: 57186-25-1 --> | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| ChEMBL = 410063 | legal_US = Rx-only
| routes_of_administration = Oral
⚫ | PubChem=105008

| SMILES = O=C5/C=C6/4(O)CC3Cc2c1ccccc1nc23(4(CC6O5C(O)(C)C)C)C
<!--Pharmacokinetic data-->
| MeSHName=Paxilline
| bioavailability =
}}
| protein_bound = >99%
|Section2={{Chembox Properties
| metabolism = ] (], ] and ]-mediated)
|C=27|H=33|N=1|O=4
| elimination_half-life = 31 hours (mean)
| MolarMass=435.56 g/mol
| excretion = Mostly fecal
| Appearance=

| Density=
<!--Identifiers-->
| MeltingPt=
| CAS_number = <!-- blanked - oldvalue: 444731-52-6 -->
| BoilingPt=
| ATC_prefix = L01
| Solubility=
| ATC_suffix = XE11
}}
| ATC_supplemental =
|Section3={{Chembox Hazards
⚫ | PubChem = 11525740
| MainHazards=
| DrugBank =
| FlashPt=
⚫ | ChemSpiderID = 9700526
| Autoignition=
| UNII_Ref = {{fdacite|correct|FDA}}
}}
| UNII = 7RN5DR86CK
| ChEMBL = <!-- blanked - oldvalue: 477772 -->
| C=21 | H=23 | N=7 | O=2 | S=1
| molecular_weight = 437.517 g/mol
| smiles = Cl.O=S(=O)(N)c1c(ccc(c1)Nc2nccc(n2)N(c4ccc3c(nn(c3C)C)c4)C)C
| StdInChI = 1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
⚫ | StdInChIKey = MQHIQUBXFFAOMK-UHFFFAOYSA-N
}} }}

Revision as of 15:57, 24 November 2011

This page contains a copy of the infobox ({{drugbox}}) taken from revid 447772444 of page Pazopanib with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa610013
License data
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding>99%
MetabolismHepatic (CYP3A4, 1A2 and 2C8-mediated)
Elimination half-life31 hours (mean)
ExcretionMostly fecal
Identifiers
IUPAC name
  • 5--2-pyrimidinyl]amino]-2-methylbenzolsulfonamide
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC21H23N7O2S
Molar mass437.517 g/mol g·mol
3D model (JSmol)
SMILES
  • Cl.O=S(=O)(N)c1c(ccc(c1)Nc2nccc(n2)N(c4ccc3c(nn(c3C)C)c4)C)C
InChI
  • InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
  • Key:MQHIQUBXFFAOMK-UHFFFAOYSA-N