Neuromedin N: Difference between revisions

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	\| PubChem=3025353		\| PubChem=3025353
	\| IUPHAR_ligand = 1578		\| IUPHAR_ligand = 1578
			\| SMILES=OC((CC(C)C)NC(((CC)C)()NC((CC1=CC=C(O)C=C1)NC(2CCCN2C((NC((N)CCCCN)=O)()(CC)C)=O)=O)=O)=O)=O
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	'''Neuromedin N''' is a ] derived from the same precursor polypeptide as ], and with similar but subtly distinct expression and effects.<ref name="pmid1463268">{{cite journal \|author=Carraway RE, Mitra SP, Spaulding G \|title=Posttranslational processing of the neurotensin/neuromedin-N precursor \|journal=Annals of the New York Academy of Sciences \|volume=668 \|issue= 1 The Neurobiol\|pages=1–16 \|year=1992 \|pmid=1463268 \|doi= 10.1111/j.1749-6632.1992.tb27335.x\|url=}}</ref><ref name="pmid1463273">{{cite journal \|author=Kitabgi P, De Nadai F, Rovère C, Bidard JN \|title=Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N \|journal=Annals of the New York Academy of Sciences \|volume=668 \|issue= 1 The Neurobiol\|pages=30–42 \|year=1992 \|pmid=1463273 \|doi= 10.1111/j.1749-6632.1992.tb27337.x\|url=}}</ref><ref name="pmid8719037">{{cite journal \|author=Vincent JP \|title=Neurotensin receptors: binding properties, transduction pathways, and structure \|journal=Cellular and Molecular Neurobiology \|volume=15 \|issue=5 \|pages=501–12 \|year=1995 \|month=October \|pmid=8719037 \|doi= 10.1007/BF02071313\|url=}}</ref><ref name="pmid11182247">{{cite journal \|author=Adams DH, Hanson GR, Keefe KA \|title=Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum \|journal=Neuroscience \|volume=102 \|issue=4 \|pages=843–51 \|year=2001 \|pmid=11182247 \|doi= 10.1016/S0306-4522(00)00530-3\|url=}}</ref><ref name="pmid11811984">{{cite journal \|author=Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C \|title=Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity \|journal=Biochemical and Biophysical Research Communications \|volume=290 \|issue=4 \|pages=1161–8 \|year=2002 \|month=February \|pmid=11811984 \|doi=10.1006/bbrc.2001.6308 \|url=}}</ref><ref name="pmid16904237">{{cite journal \|author=Kitabgi P \|title=Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases \|journal=Peptides \|volume=27 \|issue=10 \|pages=2508–14 \|year=2006 \|month=October \|pmid=16904237 \|doi=10.1016/j.peptides.2006.03.038 \|url=}}</ref>		'''Neuromedin N''' is a ] derived from the same precursor polypeptide as ], and with similar but subtly distinct expression and effects.<ref name="pmid1463268">{{cite journal \|author=Carraway RE, Mitra SP, Spaulding G \|title=Posttranslational processing of the neurotensin/neuromedin-N precursor \|journal=Annals of the New York Academy of Sciences \|volume=668 \|issue= 1 The Neurobiol\|pages=1–16 \|year=1992 \|pmid=1463268 \|doi= 10.1111/j.1749-6632.1992.tb27335.x\|url=}}</ref><ref name="pmid1463273">{{cite journal \|author=Kitabgi P, De Nadai F, Rovère C, Bidard JN \|title=Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N \|journal=Annals of the New York Academy of Sciences \|volume=668 \|issue= 1 The Neurobiol\|pages=30–42 \|year=1992 \|pmid=1463273 \|doi= 10.1111/j.1749-6632.1992.tb27337.x\|url=}}</ref><ref name="pmid8719037">{{cite journal \|author=Vincent JP \|title=Neurotensin receptors: binding properties, transduction pathways, and structure \|journal=Cellular and Molecular Neurobiology \|volume=15 \|issue=5 \|pages=501–12 \|year=1995 \|month=October \|pmid=8719037 \|doi= 10.1007/BF02071313\|url=}}</ref><ref name="pmid11182247">{{cite journal \|author=Adams DH, Hanson GR, Keefe KA \|title=Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum \|journal=Neuroscience \|volume=102 \|issue=4 \|pages=843–51 \|year=2001 \|pmid=11182247 \|doi= 10.1016/S0306-4522(00)00530-3\|url=}}</ref><ref name="pmid11811984">{{cite journal \|author=Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C \|title=Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity \|journal=Biochemical and Biophysical Research Communications \|volume=290 \|issue=4 \|pages=1161–8 \|year=2002 \|month=February \|pmid=11811984 \|doi=10.1006/bbrc.2001.6308 \|url=}}</ref><ref name="pmid16904237">{{cite journal \|author=Kitabgi P \|title=Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases \|journal=Peptides \|volume=27 \|issue=10 \|pages=2508–14 \|year=2006 \|month=October \|pmid=16904237 \|doi=10.1016/j.peptides.2006.03.038 \|url=}}</ref>

Revision as of 15:44, 4 January 2013

Neuromedin N
Identifiers

CAS Number	102577-25-3
3D model (JSmol)	Interactive image
IUPHAR/BPS	1578
PubChem CID	3025353
CompTox Dashboard (EPA)	DTXSID20145280
SMILES OC((CC(C)C)NC(((CC)C)()NC((CC1=CC=C(O)C=C1)NC(2CCCN2C((NC((N)CCCCN)=O)()(CC)C)=O)=O)=O)=O)=O
Properties
Chemical formula	C₃₈H₆₃N₇O₈
Molar mass	745.949
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is ?) Infobox references

Chemical compound

Neuromedin N
Identifiers
Symbol	NN
NCBI gene	4922
HGNC	8038
Other data
Locus	Chr. 12 q21

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.

References

Neuromedin N - Compound Summary, PubChem.
Carraway RE, Mitra SP, Spaulding G (1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 1–16. doi:10.1111/j.1749-6632.1992.tb27335.x. PMID 1463268.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Kitabgi P, De Nadai F, Rovère C, Bidard JN (1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 30–42. doi:10.1111/j.1749-6632.1992.tb27337.x. PMID 1463273.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Vincent JP (1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037. {{cite journal}}: Unknown parameter |month= ignored (help)
Adams DH, Hanson GR, Keefe KA (2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience. 102 (4): 843–51. doi:10.1016/S0306-4522(00)00530-3. PMID 11182247.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C (2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications. 290 (4): 1161–8. doi:10.1006/bbrc.2001.6308. PMID 11811984. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Kitabgi P (2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides. 27 (10): 2508–14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237. {{cite journal}}: Unknown parameter |month= ignored (help)

Peptides: neuropeptides

Hormones

see hormones

Opioid peptides

Dynorphins	Dynorphin A Dynorphin A_1–8 Dynorphin B Big dynorphin Leumorphin α-Neoendorphin β-Neoendorphin
Endomorphins	Endomorphin-1 Endomorphin-2
Endorphins	α-Endorphin β-Endorphin γ-Endorphin
Enkephalins	Met-enkephalin Leu-enkephalin
Others	Adrenorphin Amidorphin Hemorphin Hemorphin-4 Nociceptin Opiorphin Spinorphin Valorphin

Other
neuropeptides

Kinins	Bradykinins Tachykinins: mammal Substance P Neurokinin A Neurokinin B amphibian Kassinin Physalaemin
Neuromedins	B N S U
Orexins	A B
Other	Angiotensin Bombesin Calcitonin gene-related peptide Carnosine Cocaine- and amphetamine-regulated transcript Delta-sleep-inducing peptide FMRFamide Galanin Galanin-like peptide Gastrin-releasing peptide Ghrelin Neuropeptide AF Neuropeptide FF Neuropeptide SF Neuropeptide VF Neuropeptide S Neuropeptide Y Neurophysins Neurotensin Pancreatic polypeptide Pituitary adenylate cyclase-activating peptide RVD-Hpα VGF

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