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| A '''non-canonical base pairing''' is an interaction between two ] of a ] other than the standard ]ings, which are ]–] in ], adenine–] in ], and ]–] in both.<ref>{{cite journal|title=Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies|url=http://pubs.acs.org/doi/abs/10.1021/jp076921e|first1=Ashim |last1=Roy|display-authors=etal|journal=J. Phys. Chem. B|date= 2008|volume=112 |issue=12|pages=3786–3796|doi=10.1021/jp076921e}}</ref><ref>{{cite journal|url=http://www-ibmc.u-strasbg.fr/upr9002/westhof/PDF/r99_THermann_CB.pdf|title=Non-Watson-Crick base pairs in RNA-protein recognition|first1=Thomas|last1=Hermann|first2=Eric|last2=Westhof|journal=Chemistry and Biology|date=1999|issue=6|pages=335-343}}</ref> | A '''non-canonical base pairing''' is an interaction between two ] of a ] other than the standard ]ings, which are ]–] in ], adenine–] in ], and ]–] in both.<ref>{{cite journal|title=Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies|url=http://pubs.acs.org/doi/abs/10.1021/jp076921e|first1=Ashim |last1=Roy|display-authors=etal|journal=J. Phys. Chem. B|date= 2008|volume=112 |issue=12|pages=3786–3796|doi=10.1021/jp076921e}}</ref><ref>{{cite journal|url=http://www-ibmc.u-strasbg.fr/upr9002/westhof/PDF/r99_THermann_CB.pdf|title=Non-Watson-Crick base pairs in RNA-protein recognition|first1=Thomas|last1=Hermann|first2=Eric|last2=Westhof|journal=Chemistry and Biology|date=1999|issue=6|pages=335-343}}</ref> | ||
| Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140540/|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major}}</ref> | Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140540/|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major}}</ref><ref>{{cite journal|title=Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis|url=http://www.tandfonline.com/doi/abs/10.1080/07391102.2006.10507108?journalCode=tbsd20|first1=Jhuma|last1=Das|display-authors=etal|journal=Journal of Biomolecular Structure and Dynamics|volume= 24|date= 2006 |issue= 2|doi=10.1080/07391102.2006.10507108}}</ref> | ||
| ==See also== | ==See also== | ||
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A non-canonical base pairing is an interaction between two bases of a nucleic acid other than the standard base pairings, which are adenine–thymine in DNA, adenine–uracil in RNA, and cytosine–guanine in both.
Non-canonical base pairings commonly occur in the secondary structure of RNA (e.g. pairing of G with U), and in tRNA recognition. They are typically less stable than standard base pairings.
See also
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- Roy, Ashim; et al. (2008). "Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies". J. Phys. Chem. B. 112 (12): 3786–3796. doi:10.1021/jp076921e.
- Hermann, Thomas; Westhof, Eric (1999). "Non-Watson-Crick base pairs in RNA-protein recognition" (PDF). Chemistry and Biology (6): 335–343.
- Lemieux, Sébastien; Major, François (1 October 2002). "RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire". Nucleic Acids Res. 30 (19): 4250–4263.
- Das, Jhuma; et al. (2006). "Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis". Journal of Biomolecular Structure and Dynamics. 24 (2). doi:10.1080/07391102.2006.10507108.