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A '''non-canonical base pairing''' is an interaction between two ] of a ] other than the standard ]ings, which are ]–] in ], adenine–] in ], and ]–] in both.<ref>{{cite journal|title=Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies|first1=Ashim |last1=Roy|display-authors=etal|journal=J. Phys. Chem. B|date= 2008|volume=112 |issue=12|pages=3786–3796|doi=10.1021/jp076921e|pmid=18318519}}</ref> There are three main types of non-canonical base pairs: those stabilized by polar ], those having interactions among C−H and O/N groups, and those that have hydrogen bonds between the bases themselves.<ref>{{cite journal|url=http://www-ibmc.u-strasbg.fr/upr9002/westhof/PDF/r99_THermann_CB.pdf|title=Non-Watson-Crick base pairs in RNA-protein recognition|first1=Thomas|last1=Hermann|first2=Eric|last2=Westhof|journal=Chemistry and Biology|date=1999|issue=6|pages=335–343}}</ref> A '''non-canonical base pairing''' is an interaction between two ] of a ] other than the standard ]ings, which are ]–] in ], adenine–] in ], and ]–] in both.<ref>{{cite journal|title=Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies|first1=Ashim |last1=Roy|display-authors=etal|journal=J. Phys. Chem. B|date= 2008|volume=112 |issue=12|pages=3786–3796|doi=10.1021/jp076921e|pmid=18318519}}</ref> There are three main types of non-canonical base pairs: those stabilized by polar ], those having interactions among C−H and O/N groups, and those that have hydrogen bonds between the bases themselves.<ref>{{cite journal|url=http://www-ibmc.u-strasbg.fr/upr9002/westhof/PDF/r99_THermann_CB.pdf|title=Non-Watson-Crick base pairs in RNA-protein recognition|first1=Thomas|last1=Hermann|first2=Eric|last2=Westhof|journal=Chemistry and Biology|date=1999|issue=6|pages=335–343}}</ref>


Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|pmc=140540|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major|pmid=12364604}}</ref> The presence of non-canonical base pairs in double stranded DNA results in a disrupted ].<ref>{{cite journal|title=Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis|first1=Jhuma|last1=Das|display-authors=etal|journal=Journal of Biomolecular Structure and Dynamics|volume= 24|date= 2006 |issue= 2|pages=149–161|doi=10.1080/07391102.2006.10507108|pmid=16928138}}</ref> Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|pmc=140540|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major|pmid=12364604 |doi=10.1093/nar/gkf540}}</ref> The presence of non-canonical base pairs in double stranded DNA results in a disrupted ].<ref>{{cite journal|title=Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis|first1=Jhuma|last1=Das|display-authors=etal|journal=Journal of Biomolecular Structure and Dynamics|volume= 24|date= 2006 |issue= 2|pages=149–161|doi=10.1080/07391102.2006.10507108|pmid=16928138}}</ref>


==See also== ==See also==

Revision as of 10:49, 16 June 2019

A non-canonical base pairing is an interaction between two bases of a nucleic acid other than the standard base pairings, which are adenine–thymine in DNA, adenine–uracil in RNA, and cytosine–guanine in both. There are three main types of non-canonical base pairs: those stabilized by polar hydrogen bonds, those having interactions among C−H and O/N groups, and those that have hydrogen bonds between the bases themselves.

Non-canonical base pairings commonly occur in the secondary structure of RNA (e.g. pairing of G with U), and in tRNA recognition. They are typically less stable than standard base pairings. The presence of non-canonical base pairs in double stranded DNA results in a disrupted double helix.

See also

References

  1. Roy, Ashim; et al. (2008). "Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies". J. Phys. Chem. B. 112 (12): 3786–3796. doi:10.1021/jp076921e. PMID 18318519.
  2. Hermann, Thomas; Westhof, Eric (1999). "Non-Watson-Crick base pairs in RNA-protein recognition" (PDF). Chemistry and Biology (6): 335–343.
  3. Lemieux, Sébastien; Major, François (1 October 2002). "RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire". Nucleic Acids Res. 30 (19): 4250–4263. doi:10.1093/nar/gkf540. PMC 140540. PMID 12364604.
  4. Das, Jhuma; et al. (2006). "Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis". Journal of Biomolecular Structure and Dynamics. 24 (2): 149–161. doi:10.1080/07391102.2006.10507108. PMID 16928138.


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