| Revision as of 06:07, 14 November 2006 editNetscott (talk | contribs)Extended confirmed users22,834 edits rv, no original research← Previous edit | Revision as of 15:26, 22 November 2006 edit undoTom harrison (talk | contribs)Administrators47,534 editsm moved PT-141 to Bremelanotide: merging page historiesNext edit → | ||
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| '''Bremelanotide''' (formerly PT-141) is the generic term for a new ] for use in treating ] in men (] or ]) as well as sexual dysfunction in women (]). It is a ] ]. Unlike ] and other related medications, it does not act upon the vascular system, but directly increases sexual desire. Bremelanotide is a spray introduced nasally. | |||
| Originally, the ] ] that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in eight out of the ten original male volunteer test subjects. In clinical studies, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction. It is currently being tested by ]. | |||
| Bremelanotide is a cyclic hepta-] ] analog of ] (alpha-MSH) that activates the ]s ] and ] in the ]. It has the ] Ac-Nle-''cyclo''-OH or ''cyclo''-alpha-MSH-(4-10). PT-141 is a ] of ] that lacks the ] ] ]. Its molecular forumla is C<sub>50</sub>H<sub>68</sub>N<sub>14</sub>O<sub>10</sub> with a molecular weight of 1025.2. | |||
| In the ] it is currently in a ] ]. | |||
| == External links == | |||
| * The company that has developed bremelanotide. | |||
| * bremelanotide (PT-141) patent (Appl. No.:040547) | |||
| * bremelanotide (PT-141) patent (Appl. No.:066501) | |||
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| * A scientific study with female rats. | |||
| * (in German). | |||
| * The June 2006 release of summarized Phase IIa test results for women, which indicated significantly increased sexual desire and arousal (67% and 72% respectively) in women diagnosed with ]. | |||
| * Norman Levine, MD; researcherss on Melanotan at University of Arizona Dermatology | |||
| * (]; cached HTML version is ) | |||
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Revision as of 15:26, 22 November 2006
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