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| Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|pmc=140540|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major|pmid=12364604 |doi=10.1093/nar/gkf540}}</ref> The presence of non-canonical base pairs in double stranded DNA results in a disrupted ].<ref>{{cite journal|title=Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis|first1=Jhuma|last1=Das|display-authors=etal|journal=Journal of Biomolecular Structure and Dynamics|volume= 24|date= 2006 |issue= 2|pages=149–161|doi=10.1080/07391102.2006.10507108|pmid=16928138}}</ref> | Non-canonical base pairings commonly occur in the ] of RNA (e.g. pairing of G with U), and in ] recognition. They are typically ] than standard base pairings.<ref>{{cite journal|title=RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire|pmc=140540|journal=Nucleic Acids Res. |date=1 October 2002|volume=30|issue=19|pages=4250–4263|first1=Sébastien |last1=Lemieux |first2=François |last2=Major|pmid=12364604 |doi=10.1093/nar/gkf540}}</ref> The presence of non-canonical base pairs in double stranded DNA results in a disrupted ].<ref>{{cite journal|title=Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis|first1=Jhuma|last1=Das|display-authors=etal|journal=Journal of Biomolecular Structure and Dynamics|volume= 24|date= 2006 |issue= 2|pages=149–161|doi=10.1080/07391102.2006.10507108|pmid=16928138}}</ref> | ||
| == History == | |||
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| ==See also== | ==See also== | ||
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Revision as of 23:51, 18 November 2019
A non-canonical base pairing is an interaction between two bases of a nucleic acid other than the standard base pairings, which are adenine–thymine in DNA, adenine–uracil in RNA, and cytosine–guanine in both. There are three main types of non-canonical base pairs: those stabilized by polar hydrogen bonds, those having interactions among C−H and O/N groups, and those that have hydrogen bonds between the bases themselves.
Non-canonical base pairings commonly occur in the secondary structure of RNA (e.g. pairing of G with U), and in tRNA recognition. They are typically less stable than standard base pairings. The presence of non-canonical base pairs in double stranded DNA results in a disrupted double helix.
History
See also
References
- Roy, Ashim; et al. (2008). "Structure, Stability, and Dynamics of Canonical and Noncanonical Base Pairs: Quantum Chemical Studies". J. Phys. Chem. B. 112 (12): 3786–3796. doi:10.1021/jp076921e. PMID 18318519.
- Hermann, Thomas; Westhof, Eric (1999). "Non-Watson-Crick base pairs in RNA-protein recognition" (PDF). Chemistry and Biology (6): 335–343.
- Lemieux, Sébastien; Major, François (1 October 2002). "RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire". Nucleic Acids Res. 30 (19): 4250–4263. doi:10.1093/nar/gkf540. PMC 140540. PMID 12364604.
- Das, Jhuma; et al. (2006). "Non-Canonical Base Pairs and Higher Order Structures in Nucleic Acids: Crystal Structure Database Analysis". Journal of Biomolecular Structure and Dynamics. 24 (2): 149–161. doi:10.1080/07391102.2006.10507108. PMID 16928138.
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