Misplaced Pages

Salubrinal: Difference between revisions

Article snapshot taken from[REDACTED] with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editNext edit →Content deleted Content addedVisualWikitext
Revision as of 23:39, 13 September 2021 editLentower (talk | contribs)Extended confirmed users24,492 edits →References: add portal← Previous edit Revision as of 05:21, 5 October 2021 edit undoCitation bot (talk | contribs)Bots5,459,784 edits Add: doi-access. | Use this bot. Report bugs. | Suggested by Headbomb | Linked from Misplaced Pages:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | #UCB_webform_linked 641/990Next edit →
Line 76: Line 76:
<ref name="dk1">{{cite journal | vauthors = Kessel D | title = Protection of Bcl-2 by salubrinal | journal = Biochemical and Biophysical Research Communications | volume = 346 | issue = 4 | pages = 1320–3 | date = August 2006 | pmid = 16806073 | pmc = 2978664 | doi = 10.1016/j.bbrc.2006.06.056 | publisher = Elsevier Inc }}{{dead link|date=March 2019|bot=medic}}{{cbignore|bot=medic}}</ref> <ref name="dk1">{{cite journal | vauthors = Kessel D | title = Protection of Bcl-2 by salubrinal | journal = Biochemical and Biophysical Research Communications | volume = 346 | issue = 4 | pages = 1320–3 | date = August 2006 | pmid = 16806073 | pmc = 2978664 | doi = 10.1016/j.bbrc.2006.06.056 | publisher = Elsevier Inc }}{{dead link|date=March 2019|bot=medic}}{{cbignore|bot=medic}}</ref>


<ref name="jl1">{{cite journal | vauthors = Lewerenz J, Maher P | title = Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression | journal = The Journal of Biological Chemistry | volume = 284 | issue = 2 | pages = 1106–15 | date = January 2009 | pmid = 19017641 | pmc = 2613630 | doi = 10.1074/jbc.M807325200 | publisher = The American Society for Biochemistry and Molecular Biology, Inc }}</ref> <ref name="jl1">{{cite journal | vauthors = Lewerenz J, Maher P | title = Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression | journal = The Journal of Biological Chemistry | volume = 284 | issue = 2 | pages = 1106–15 | date = January 2009 | pmid = 19017641 | pmc = 2613630 | doi = 10.1074/jbc.M807325200 | publisher = The American Society for Biochemistry and Molecular Biology, Inc | doi-access = free }}</ref>


<ref name="bm1">{{cite journal | vauthors = Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J | display-authors = 6 | title = A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress | journal = Science | volume = 307 | issue = 5711 | pages = 935–9 | date = February 2005 | pmid = 15705855 | doi = 10.1126/science.1101902 | bibcode = 2005Sci...307..935B | s2cid = 86257684 | url = http://www.sciencemag.org/cgi/content/abstract/307/5711/935 }}</ref> <ref name="bm1">{{cite journal | vauthors = Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J | display-authors = 6 | title = A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress | journal = Science | volume = 307 | issue = 5711 | pages = 935–9 | date = February 2005 | pmid = 15705855 | doi = 10.1126/science.1101902 | bibcode = 2005Sci...307..935B | s2cid = 86257684 | url = http://www.sciencemag.org/cgi/content/abstract/307/5711/935 }}</ref>

Revision as of 05:21, 5 October 2021

Pharmaceutical compound
Salubrinal
Identifiers
IUPAC name
  • 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
CAS Number
PubChem CID
ChemSpider
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.237.268 Edit this at Wikidata
Chemical and physical data
FormulaC21H17Cl3N4OS
Molar mass479.80 g·mol
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
InChI
  • InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
  • Key:LCOIAYJMPKXARU-VAWYXSNFSA-N
  (what is this?)  (verify)

Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit, resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal has putative therapeutic value due to its function, but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.

References

  1. ^ Lewerenz J, Maher P (January 2009). "Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression". The Journal of Biological Chemistry. 284 (2). The American Society for Biochemistry and Molecular Biology, Inc: 1106–15. doi:10.1074/jbc.M807325200. PMC 2613630. PMID 19017641.
  2. Kessel D (August 2006). "Protection of Bcl-2 by salubrinal". Biochemical and Biophysical Research Communications. 346 (4). Elsevier Inc: 1320–3. doi:10.1016/j.bbrc.2006.06.056. PMC 2978664. PMID 16806073.
  3. ^ Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, et al. (February 2005). "A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress". Science. 307 (5711): 935–9. Bibcode:2005Sci...307..935B. doi:10.1126/science.1101902. PMID 15705855. S2CID 86257684.
  4. "Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2010-10-05.
  5. Wek RC, Jiang HY, Anthony TG (February 2006). "Coping with stress: eIF2 kinases and translational control". Biochemical Society Transactions. 34 (Pt 1). Biochemical Society: 7–11. doi:10.1042/BST20060007. PMID 16246168.
  6. "New compound may accelerate bone healing, prevent osteoporosis". August 2011. Archived from the original on 29 September 2011. Retrieved 2011-08-29.
Categories:
Salubrinal: Difference between revisions Add topic