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| The '''Warburg effect''' is the inhibition of ] fixation, and subsequently ], by high ] concentrations. The effect is named for ]. The oxygenase activity of ], which initiates the process of ], largely accounts for the Warburg effect. In humans, the Warburg Effect causes cancer cells to rely preferentially on glycolysis for ] (ATP) production unlike normal healthy cells. Because ] (NAD) is a cofactor required for ], by blocking the production of NAD the cancerous cell will eventually die apoptotically. This allows for the creation of ] drugs by targeting specific fast growing, NAD reliant cells. | The '''Warburg effect''' is the inhibition of ] fixation, and subsequently ], by high ] concentrations. The effect is named for ]. The oxygenase activity of ], which initiates the process of ], largely accounts for the Warburg effect. In humans, the Warburg Effect causes cancer cells to rely preferentially on glycolysis for ] (ATP) production unlike normal healthy cells. Because ] (NAD) is a cofactor required for ], by blocking the production of NAD the cancerous cell will eventually die apoptotically. This allows for the creation of ] drugs by targeting specific fast growing, NAD reliant cells. | ||
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Revision as of 12:16, 14 February 2007
The Warburg effect is the inhibition of carbon dioxide fixation, and subsequently photosynthesis, by high oxygen concentrations. The effect is named for Otto Heinrich Warburg. The oxygenase activity of RuBisCO, which initiates the process of photorespiration, largely accounts for the Warburg effect. In humans, the Warburg Effect causes cancer cells to rely preferentially on glycolysis for adenosine triphosphate (ATP) production unlike normal healthy cells. Because nicotinamide adenine dinucleotide (NAD) is a cofactor required for glycolysis, by blocking the production of NAD the cancerous cell will eventually die apoptotically. This allows for the creation of chemotherapy drugs by targeting specific fast growing, NAD reliant cells.
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