Impromidine: Difference between revisions

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Latest revision as of 17:37, 11 January 2023

Chemical compound Pharmaceutical compound

Impromidine
Clinical data


ATC code	none
Identifiers
IUPAC name 2--1-ethyl]guanidine
CAS Number	55273-05-7
PubChem CID	41376
IUPHAR/BPS	1226
ChemSpider	37757
UNII	931L4X5WMM
ChEMBL	ChEMBL12608
CompTox Dashboard (EPA)	DTXSID90203780
Chemical and physical data
Formula	C₁₄H₂₃N₇S
Molar mass	321.45 g·mol
3D model (JSmol)	Interactive image
SMILES Cc1cnc1CSCCNC(=N)NCCCc2ccn2
InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18) Key:MURRAGMMNAYLNA-UHFFFAOYSA-N
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Impromidine (INN) is a highly potent and specific histamine H₂ receptor agonist.

It has been used diagnostically as a gastric secretion indicator.

Durant G, Duncan W, Ganellin C, Parsons M, Blakemore R, Rasmussen A (1978). "Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors". Nature. 276 (5686): 403–5. doi:10.1038/276403a0. PMID 714166. S2CID 4242863.

Agonists

Antagonists

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

Agonists	α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L-Histidine Methimepip Proxyfan
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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