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'''Terpinen-4-ol''' is an isomer of ] with the chemical formula C<sub>10</sub>H<sub>18</sub>O. A primary constituent of ],<ref name="lact">{{cite web |title=Tea tree oil |url=https://www.ncbi.nlm.nih.gov/books/NBK501884/ |publisher=Drugs and Lactation Database (LactMed), National Library of Medicine, US National Institutes of Health |accessdate=31 July 2019 |date=3 December 2018}}</ref> it is obtained as an ] from the leaves, branches, and bark of '']'' Cheel.<ref name="drugs">{{cite web |title=Tea tree oil |url=https://www.drugs.com/npp/tea-tree-oil.html |publisher=Drugs.com |accessdate=31 July 2019 |date=17 June 2019}}</ref><ref name="Groot">{{cite journal | last=de Groot | first=Anton C. | last2=Schmidt | first2=Erich | title=Tea tree oil: contact allergy and chemical composition | journal=Contact Dermatitis | volume=75 | issue=3 | date=13 May 2016 | issn=0105-1873 | doi=10.1111/cod.12591 | pages=129–143| doi-access=free }}</ref><ref>{{ cite journal | author = Hammer, K. A.; Carson, C. F.; Riley, T. V. | title = Effects of ''Melaleuca alternifolia'' (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility | journal = Antimicrobial Agents and Chemotherapy | year = 2012 | volume = 56 | issue = 2 | pages = 909–915 | doi = 10.1128/AAC.05741-11 | pmid = 22083482 | pmc = 3264233 }}</ref> Despite considerable ] and preliminary ] of terpinen-4-ol and tea tree oil, its biological properties and potential for clinical uses have not been established as of 2019.<ref name=drugs/> It may be a factor in the ] of tea tree oil when used ].<ref name=drugs/><ref name=Groot/> '''Terpinen-4-ol''' is an isomer of ] with the chemical formula C<sub>10</sub>H<sub>18</sub>O. A primary constituent of ],<ref name="lact">{{cite web |title=Tea tree oil |url=https://www.ncbi.nlm.nih.gov/books/NBK501884/ |publisher=Drugs and Lactation Database (LactMed), National Library of Medicine, US National Institutes of Health |accessdate=31 July 2019 |date=3 December 2018}}</ref> it is obtained as an ] from the leaves, branches, and bark of '']'' Cheel.<ref name="drugs">{{cite web |title=Tea tree oil |url=https://www.drugs.com/npp/tea-tree-oil.html |publisher=Drugs.com |accessdate=31 July 2019 |date=17 June 2019}}</ref><ref name="Groot">{{cite journal | last1=de Groot | first1=Anton C. | last2=Schmidt | first2=Erich | title=Tea tree oil: contact allergy and chemical composition | journal=Contact Dermatitis | volume=75 | issue=3 | date=13 May 2016 | issn=0105-1873 | doi=10.1111/cod.12591 | pages=129–143| pmid=27173437 | doi-access=free }}</ref><ref>{{ cite journal | author = Hammer, K. A.; Carson, C. F.; Riley, T. V. | title = Effects of ''Melaleuca alternifolia'' (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility | journal = Antimicrobial Agents and Chemotherapy | year = 2012 | volume = 56 | issue = 2 | pages = 909–915 | doi = 10.1128/AAC.05741-11 | pmid = 22083482 | pmc = 3264233 }}</ref> Despite considerable ] and preliminary ] of terpinen-4-ol and tea tree oil, its biological properties and potential for clinical uses have not been established as of 2019.<ref name=drugs/> It may be a factor in the ] of tea tree oil when used ].<ref name=drugs/><ref name=Groot/>


Terpinen-4-ol occurs in '']'' and is thought to be the reason why this wood is highly resistant to ]. {{citation needed|date=July 2019}} Terpinen-4-ol occurs in '']'' and is thought to be the reason why this wood is highly resistant to ]. {{citation needed|date=July 2019}}

Revision as of 20:50, 1 March 2023

Terpinen-4-ol
Names
Preferred IUPAC name 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.008.396 Edit this at Wikidata
MeSH terpinenol-4
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H18O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,8,11H,5-7H2,1-3H3Key: WRYLYDPHFGVWKC-UHFFFAOYSA-N
  • InChI=1/C10H18O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,8,11H,5-7H2,1-3H3Key: WRYLYDPHFGVWKC-UHFFFAOYAQ
SMILES
  • CC1=CCC(CC1)(C(C)C)O
Properties
Chemical formula C10H18O
Molar mass 154.253 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Terpinen-4-ol is an isomer of terpineol with the chemical formula C10H18O. A primary constituent of tea tree oil, it is obtained as an extract from the leaves, branches, and bark of Melaleuca alternifolia Cheel. Despite considerable basic and preliminary clinical research of terpinen-4-ol and tea tree oil, its biological properties and potential for clinical uses have not been established as of 2019. It may be a factor in the contact dermatitis of tea tree oil when used topically.

Terpinen-4-ol occurs in Juniperus communis and is thought to be the reason why this wood is highly resistant to rot.

Additional images

Synthesis

References

  1. "Tea tree oil". Drugs and Lactation Database (LactMed), National Library of Medicine, US National Institutes of Health. 3 December 2018. Retrieved 31 July 2019.
  2. ^ "Tea tree oil". Drugs.com. 17 June 2019. Retrieved 31 July 2019.
  3. ^ de Groot, Anton C.; Schmidt, Erich (13 May 2016). "Tea tree oil: contact allergy and chemical composition". Contact Dermatitis. 75 (3): 129–143. doi:10.1111/cod.12591. ISSN 0105-1873. PMID 27173437.
  4. Hammer, K. A.; Carson, C. F.; Riley, T. V. (2012). "Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility". Antimicrobial Agents and Chemotherapy. 56 (2): 909–915. doi:10.1128/AAC.05741-11. PMC 3264233. PMID 22083482.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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