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Revision as of 15:47, 18 March 2023 editSmokefoot (talk \| contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers74,619 edits expand← Previous edit		Revision as of 16:08, 18 March 2023 edit undoSmokefoot (talk \| contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers74,619 edits thumb\|sequence of oxidation of ureate Next edit →
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	'''5-Hydroxyisourate''' is an ] that is produced by the ] of ]. The conversion is a major pathway in the antioxidant properties of ureate. The conversion is catalysed by ].<ref>{{cite book \|author =Perry A. Frey,Dexter B. Northrop \| title =Enzymatic mechanisms \| date =1999 \| publisher = IOS Press \| isbn = 978-9051994322 }}</ref><ref>{{cite book \| author =Richard B. Silverman \| title =The organic chemistry of enzyme-catalyzed reactions \| date =2002 \| publisher = Academic Press \| isbn = 978-0-12-643731-7}}</ref><ref>{{cite journal \|doi=10.1007/s00253-010-2455-0\|title=Cofactor-independent oxidases and oxygenases \|year=2010 \|last1=Fetzner \|first1=Susanne \|last2=Steiner \|first2=Roberto A. \|journal=Applied Microbiology and Biotechnology \|volume=86 \|issue=3 \|pages=791–804 \|pmid=20157809 \|s2cid=25377247 }}</ref>		'''5-Hydroxyisourate''' is an ] that is produced by the ] of ]. The conversion is a major pathway in the antioxidant properties of ureate. The conversion is catalysed by ].<ref>{{cite book \|author =Perry A. Frey,Dexter B. Northrop \| title =Enzymatic mechanisms \| date =1999 \| publisher = IOS Press \| isbn = 978-9051994322 }}</ref><ref>{{cite book \| author =Richard B. Silverman \| title =The organic chemistry of enzyme-catalyzed reactions \| date =2002 \| publisher = Academic Press \| isbn = 978-0-12-643731-7}}</ref><ref>{{cite journal \|doi=10.1007/s00253-010-2455-0\|title=Cofactor-independent oxidases and oxygenases \|year=2010 \|last1=Fetzner \|first1=Susanne \|last2=Steiner \|first2=Roberto A. \|journal=Applied Microbiology and Biotechnology \|volume=86 \|issue=3 \|pages=791–804 \|pmid=20157809 \|s2cid=25377247 }}</ref>
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	==References==		==References==
	{{reflist}}		{{reflist}}

Revision as of 16:08, 18 March 2023

5-Hydroxyisourate
Names

IUPAC name 5-hydroxy-3,7-dihydropurine-2,6,8-trione
Identifiers
CAS Number	6960-30-1
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:18072
ChemSpider	219288
KEGG	C11821
MeSH	5-Hydroxyisourate
PubChem CID	250388
UNII	DU6PJ7L9BX
CompTox Dashboard (EPA)	DTXSID10290591
InChI InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYSA-N InChI=1/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYAS
SMILES C12=NC(=O)NC1(C(=O)NC(=O)N2)O O=C1NC(=O)N/C2=N/C(=O)NC12O
Properties
Chemical formula	C₅H₄N₄O₄
Molar mass	184.11 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

5-Hydroxyisourate is an organic compound that is produced by the oxidation of uric acid. The conversion is a major pathway in the antioxidant properties of ureate. The conversion is catalysed by urate oxidase.

sequence of oxidation of ureate

References

Perry A. Frey,Dexter B. Northrop (1999). Enzymatic mechanisms. IOS Press. ISBN 978-9051994322.
Richard B. Silverman (2002). The organic chemistry of enzyme-catalyzed reactions. Academic Press. ISBN 978-0-12-643731-7.
Fetzner, Susanne; Steiner, Roberto A. (2010). "Cofactor-independent oxidases and oxygenases". Applied Microbiology and Biotechnology. 86 (3): 791–804. doi:10.1007/s00253-010-2455-0. PMID 20157809. S2CID 25377247.

See also

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Nucleotide metabolic intermediates

purine
metabolism

anabolism

R5P→IMP:	Ribose 5-phosphate (R5P) Phosphoribosyl pyrophosphate (PRPP) Phosphoribosylamine (PRA) Glycineamide ribonucleotide (GAR) Phosphoribosyl-N-formylglycineamide (FGAR) 5′-Phosphoribosylformylglycinamidine (FGAM) 5-Aminoimidazole ribotide (AIR) 5′-Phosphoribosyl-4-carboxy-5-aminoimidazole (CAIR) Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) AICA ribonucleotide (AICAR) 5-Formamidoimidazole-4-carboxamide ribotide (FAICAR)
IMP→AMP:	Adenylosuccinate
IMP→GMP:	Xanthosine monophosphate

catabolism

pyrimidine
metabolism

anabolism

catabolism

uracil:	β-Alanine Dihydrouracil 3-Ureidopropionic acid
thymine:	3-Aminoisobutyric acid Dihydrothymine β-Ureidoisobutyric acid

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