| Revision as of 22:45, 20 September 2024 editKeliansoh (talk | contribs)37 edits Created a Misplaced Pages page for C15orf62: Introduction, headings, links, citations, figureTag: Visual edit | Revision as of 23:35, 20 September 2024 edit undoKeliansoh (talk | contribs)37 edits Added referencesTag: Visual editNext edit → | ||
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| == Homology == | == Homology == | ||
| ⚫ | Paralogs | ||
| ⚫ | === Paralogs === | ||
| The protein has no apparent paralogs based on Blast performed on ]. | The protein has no apparent paralogs based on Blast performed on ]. | ||
| Orthologs | === Orthologs === | ||
| == Proteins == | == Proteins == | ||
| ⚫ | Sequence | ||
| ⚫ | === Sequence === | ||
| ⚫ | Modifications | ||
| ⚫ | === Modifications === | ||
| ⚫ | Structure | ||
| ⚫ | === Structure === | ||
| == Function == | == Function == | ||
| Expression | === Expression === | ||
| C15orf62 is expressed primarily in the lungs of normal human tissue ]. | C15orf62 is expressed primarily in the lungs of normal human tissue ]. | ||
| == Clinical Significance == | == Clinical Significance == | ||
| C15orf62 has been identified has a methylene driven gene in thyroid cancer. Hypomethylation causes gene over-expression, and hypermethylation leads to low gene expression, both key factors in tumor development.<ref>{{Cite journal |last=Chen |first=Zhiwei |last2=Liu |first2=Xiaoli |last3=Liu |first3=Fangfang |last4=Zhang |first4=Guolie |last5=Tu |first5=Haijian |last6=Lin |first6=Wei |last7=Lin |first7=Haifeng |date=2021-08-29 |title=Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436924/ |journal=Aging (Albany NY) |volume=13 |issue=16 |pages=20164–20178 |doi=10.18632/aging.203338 |issn=1945-4589 |pmc=8436924 |pmid=34456184}}</ref> C15orf62 has been linked to breast cancer susceptibility performing a role mitochondrial ribosomal biogenesis, assembling ].<ref>{{Cite journal |last=Podder |first=Bristy Rani |last2=Kheya |first2=Ilora Shabnam |last3=Elias |first3=Sabrina Moriom |date=2024-02-01 |title=Breast cancer risk SNPs and associated expression QTLs focusing Bangladeshi population: An in silico analysis |url=https://www.sciencedirect.com/science/article/pii/S2773044124000147 |journal=Human Gene |volume=39 |pages=201270 |doi=10.1016/j.humgen.2024.201270 |issn=2773-0441}}</ref> | |||
| == References == | == References == | ||
Revision as of 23:35, 20 September 2024
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C15orf62
C15orf62, also known as chromosome 15 open reading frame 62, is a protein-coding gene variant (NM_001130448.3) with a molecular weight of 19679 Da. The C15orf62 gene is localized in the mitochondria of the cell and exhibits relatively low expression across most human tissues.
Gene
The gene has a base pair length of 2,470 and contains 1 exon encoding for 175 amino acid protein.
Locus
C15orf62 is located on cytogenetic band 15q15.1 and is plus-strand oriented.
Transcript
Homology
Paralogs
The protein has no apparent paralogs based on Blast performed on NCBI.
Orthologs
Proteins
Sequence
Modifications
Structure
Function
Expression
C15orf62 is expressed primarily in the lungs of normal human tissue mRNA.
Clinical Significance
C15orf62 has been identified has a methylene driven gene in thyroid cancer. Hypomethylation causes gene over-expression, and hypermethylation leads to low gene expression, both key factors in tumor development. C15orf62 has been linked to breast cancer susceptibility performing a role mitochondrial ribosomal biogenesis, assembling mitochondrial ribosomes.
References
- "C15orf62 chromosome 15 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-09-20.
- Chen, Zhiwei; Liu, Xiaoli; Liu, Fangfang; Zhang, Guolie; Tu, Haijian; Lin, Wei; Lin, Haifeng (2021-08-29). "Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm". Aging (Albany NY). 13 (16): 20164–20178. doi:10.18632/aging.203338. ISSN 1945-4589. PMC 8436924. PMID 34456184.
- Podder, Bristy Rani; Kheya, Ilora Shabnam; Elias, Sabrina Moriom (2024-02-01). "Breast cancer risk SNPs and associated expression QTLs focusing Bangladeshi population: An in silico analysis". Human Gene. 39: 201270. doi:10.1016/j.humgen.2024.201270. ISSN 2773-0441.