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This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages) This article needs to be updated. The reason given is: Leone stopped working with the organization even before it shut down in 2014.. Please help update this article to reflect recent events or newly available information. (May 2024) The topic of this article may not meet Misplaced Pages's notability guideline for academics. Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be shown, the article is likely to be merged, redirected, or deleted. Find sources: "Paola Leone" – news · newspapers · books · scholar · JSTOR (November 2022) (Learn how and when to remove this message) This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. Please help improve it by replacing them with more appropriate citations to reliable, independent, third-party sources. (November 2022) (Learn how and when to remove this message) (Learn how and when to remove this message)

Paola Leone is an Italian researcher of Canavan disease, a leukodystrophy.

Leone was born and raised in Cagliari, Italy. She received her undergraduate and graduate training in Italy, followed by post-doctoral studies in Montreal and Yale University in New Haven, CT. She holds a doctorate degree in Neuroscience from the University of Padua. Her work on Canavan disease started at Yale, where she collaborated with other early pioneers in gene therapy. She left Yale in 1998 to join the (now defunct) Cell & Gene Therapy Center at Thomas Jefferson University in Philadelphia. She directs The Cell & Gene Therapy Center at the University of Medicine and Dentistry of New Jersey.

Recently, she has been funded by NIH-NINDS and Jacob's Cure to study the potential of subpopulations of stem cells to promote remyelination and phenotypic rescue in animal models of white matter disease, including the Canavan mouse model. She is generating pre-clinical data using human Embryonic-Derived-Oligodendrocyte Stem Cells provided by Geron Corporation (CA). These studies will provide a foundation for a targeted and comprehensive analysis of the potential of a cell-based therapy for Canavan Disease.

References

1. University of Medicine and Dentistry of New Jersey - Faculty and Research Interests
2. University of Medicine and Dentistry of New Jersey - Cell and Gene Therapy Center Faculty and Staff Archived 2009-03-25 at archive.today.
3. "On the cusp of a cure for deadly childhood disease". today.rowan.edu. Retrieved 2020-12-28.
4. Ph.D, Miryam Z. Wahrman. "Looking for cures". jewishstandard.timesofisrael.com. Retrieved 2020-12-28.
5. Jacob's Cure Canavan Disease Research -

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