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Revision as of 11:33, 31 December 2024

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Pharmaceutical compound
Ateganosine
Clinical data
Other names2'-Deoxythioguanosine
Identifiers
IUPAC name
  • 2-amino-9--3H-purine-6-thione
CAS Number
PubChem CID
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H13N5O3S
Molar mass283.31 g·mol
3D model (JSmol)
SMILES
  • C1((O1N2C=NC3=C2NC(=NC3=S)N)CO)O
InChI
  • InChI=InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
  • Key:SCVJRXQHFJXZFZ-KVQBGUIXSA-N

Ateganosine is a telomerase inhibitor and apoptosis inducer currently under investigation for the treatment of various cancers, including non-small cell lung cancer (NSCLC).

References

  1. Eglenen-Polat B, Kowash RR, Huang HC, Siteni S, Zhu M, Chen K, et al. (January 2024). "A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer". Nature Communications. 15 (1): 672. doi:10.1038/s41467-024-44861-8. PMC 10803750. PMID 38253555.
  2. "Ateganosine". PatSnap.


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