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⚫ '''Trideca-7,9,11-trienoic acid''', or '''(7E,9E,11E)-trideca-7,9,11-trienoic acid''', is an ]. It is present in '']''.<ref name="three">{{cite journal |last1=Shri |first1=Richa |last2=Bhutani |first2=K.K. |last3=Sharma |first3=Anupam |year=2010 |title=A new anxiolytic fatty acid from Aethusa cynapium |journal=Fitoterapia |volume=81 |issue=5 |pages=337–340 |doi=10.1016/j.fitote.2010.05.003}}</ref><ref name="four">{{Cite web |title=(7E,9E,11E)-trideca-7,9,11-trienoic acid |publisher=National Library of Medicine |work=PubChem |url=https://pubchem.ncbi.nlm.nih.gov/compound/(7E-9E-11E)-trideca-7-9-11-trienoic-acid}} 3.1.2025.</ref><ref name="five">{{Cite patent |title=Composition for ink vehicles and protective coatings |publication-number=EP0503897A1 |inventor=Gerald Sugarman, Michael W. O'Neill |assignee=Topez Co|url=https://patents.google.com/patent/EP0503897A1}} 16.9.1992.</ref>


== Pharmacology ==
⚫ '''Trideca-7,9,11-trienoic acid''', or '''(7E,9E,11E)-trideca-7,9,11-trienoic acid''', is an ]. It is present in '']''. It has been shown to have an antianxiety effect in '']'', '']'', and '']''. It causes hypolocomotion in ''Mus musculus'' and ''Rattus norvegicus''. A 2mg/Kg dose of ] has a very similiar effect to 20mg/Kg of trideca-7,9,11-trienoic acid.<ref name="three">{{cite journal |last1=Shri |first1=Richa |last2=Bhutani |first2=K.K. |last3=Sharma |first3=Anupam |year=2010 |title=A new anxiolytic fatty acid from Aethusa cynapium |journal=Fitoterapia |volume=81 |issue=5 |pages=337–340 |doi=10.1016/j.fitote.2010.05.003}}</ref><ref>{{cite patent }}Compounds and compositions for treating CNS disorders, Kerry L. Spear, Douglas Burdi, WO2021138314A1, WIPO, 8.7.2021. (https://patents.google.com/patent/WO2021138314A1/en)</ref><ref>{{Cite web |title=(7E,9E,11E)-trideca-7,9,11-trienoic acid |publisher=National Library of Medicine |work=PubChem |url=https://pubchem.ncbi.nlm.nih.gov/compound/(7E-9E-11E)-trideca-7-9-11-trienoic-acid}} 3.1.2025.</ref><ref>{{Cite patent |title=Composition for ink vehicles and protective coatings |publication-number=EP0503897A1 |inventor=Gerald Sugarman, Michael W. O'Neill |assignee=Topez Co |date=1992-09-16 |url=https://patents.google.com/patent/EP0503897A1}}</ref>
It has been shown to have an ] effect in '']'', '']'', and '']''. It reduces ] caused by anxiety, which was ] induced with ], in ''Mus musculus'' and ''Rattus norvegicus''. A 2mg/Kg dose of ] has a very similiar effect to 20mg/Kg of trideca-7,9,11-trienoic acid.<ref name="three" /><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Szabados T |title=mCPP-induced anxiety—a potential new method for screening anxiolytic activity |journal=Neurobiology |year=1996 |volume=4 |pages=253–5}}</ref><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Levay G |title=mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity |journal=Psychopharmacology |year=1998 |volume=136 |pages=291–8}}</ref>


==References== ==References==

Revision as of 02:59, 3 January 2025

Trideca-7,9,11-trienoic acid
Names
IUPAC name (7E,9E,11E)-trideca-7,9,11-trienoic acid
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
InChI
  • InChI=1S/C13H20O2/c1-2-3-4-5-6-7-8-9-10-11-12-13(14)15/h2-7H,8-12H2,1H3,(H,14,15)/b3-2+,5-4+,7-6+¨Key: CMKVWQNTXKWDNT-ICDJNDDTSA-N
SMILES
  • C/C=C/C=C/C=C/CCCCCC(=O)O
Properties
Chemical formula C13H20O2
Molar mass 208.301 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Trideca-7,9,11-trienoic acid, or (7E,9E,11E)-trideca-7,9,11-trienoic acid, is an polyunsaturated fatty acid. It is present in Aethusa cynapium.

Pharmacology

It has been shown to have an antianxiety effect in Mus musculus, Rattus norvegicus, and Homo sapiens. It reduces hypolocomotion caused by anxiety, which was psychopharmacologically induced with mCPP, in Mus musculus and Rattus norvegicus. A 2mg/Kg dose of diazepam has a very similiar effect to 20mg/Kg of trideca-7,9,11-trienoic acid.

References

  1. ^ Shri, Richa; Bhutani, K.K.; Sharma, Anupam (2010). "A new anxiolytic fatty acid from Aethusa cynapium". Fitoterapia. 81 (5): 337–340. doi:10.1016/j.fitote.2010.05.003.
  2. "(7E,9E,11E)-trideca-7,9,11-trienoic acid". PubChem. National Library of Medicine. 3.1.2025.
  3. EP0503897A1, Gerald Sugarman, Michael W. O'Neill, "Composition for ink vehicles and protective coatings", assigned to Topez Co  16.9.1992.
  4. Bilkei-Gorzo A, Gyertyar I, Szabados T (1996). "mCPP-induced anxiety—a potential new method for screening anxiolytic activity". Neurobiology. 4: 253–5.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Bilkei-Gorzo A, Gyertyar I, Levay G (1998). "mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity". Psychopharmacology. 136: 291–8.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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