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== Pharmacology == == Pharmacology ==
Trideca-7,9,11-trienoic acid has been shown to have an ] effect in '']'', '']'', and '']''. It reduces ] caused by anxiety, which was ] induced with ], in ''Mus musculus'' and ''Rattus norvegicus''. A 2&nbsp;mg/Kg dose of ] has a very similar effect to 20&nbsp;mg/Kg of trideca-7,9,11-trienoic acid.<ref name="three" /><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Szabados T |title=mCPP-induced anxiety—a potential new method for screening anxiolytic activity |journal=Neurobiology |year=1996 |volume=4 |pages=253–5}}</ref><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Levay G |title=mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity |journal=Psychopharmacology |year=1998 |volume=136 |pages=291–8}}</ref> Trideca-7,9,11-trienoic acid has been shown to have an ] effect in '']'', '']'', and '']''. It reduces ] caused by anxiety, which was ] induced with ], in ''Mus musculus'' and ''Rattus norvegicus''. A 2&nbsp;mg/Kg dose of ] has a very similar effect to 20&nbsp;mg/Kg of trideca-7,9,11-trienoic acid. This may suggest that trideca-7,9,11-trienoic acid is also a ] agonist like diazepam.<ref name="three" /><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Szabados T |title=mCPP-induced anxiety—a potential new method for screening anxiolytic activity |journal=Neurobiology |year=1996 |volume=4 |pages=253–5}}</ref><ref>{{cite journal |author=Bilkei-Gorzo A, Gyertyar I, Levay G |title=mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity |journal=Psychopharmacology |year=1998 |volume=136 |pages=291–8}}</ref><ref name="pmid18384456">{{cite journal | vauthors = Riss J, Cloyd J, Gates J, Collins S | title = Benzodiazepines in epilepsy: pharmacology and pharmacokinetics | journal = Acta Neurologica Scandinavica | volume = 118 | issue = 2 | pages = 69–86 | date = August 2008 | pmid = 18384456 | doi = 10.1111/j.1600-0404.2008.01004.x | s2cid = 24453988 | doi-access = free }}</ref>


== Extraction from ''A. cynapium'' == == Extraction from ''A. cynapium'' ==

Revision as of 03:29, 3 January 2025

Trideca-7,9,11-trienoic acid
Names
IUPAC name (7E,9E,11E)-trideca-7,9,11-trienoic acid
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
InChI
  • InChI=1S/C13H20O2/c1-2-3-4-5-6-7-8-9-10-11-12-13(14)15/h2-7H,8-12H2,1H3,(H,14,15)/b3-2+,5-4+,7-6+¨Key: CMKVWQNTXKWDNT-ICDJNDDTSA-N
SMILES
  • C/C=C/C=C/C=C/CCCCCC(=O)O
Properties
Chemical formula C13H20O2
Molar mass 208.301 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Trideca-7,9,11-trienoic acid, or (7E,9E,11E)-trideca-7,9,11-trienoic acid, is an polyunsaturated fatty acid. It is present in Aethusa cynapium.

Pharmacology

Trideca-7,9,11-trienoic acid has been shown to have an antianxiety effect in Mus musculus, Rattus norvegicus, and Homo sapiens. It reduces hypolocomotion caused by anxiety, which was psychopharmacologically induced with mCPP, in Mus musculus and Rattus norvegicus. A 2 mg/Kg dose of diazepam has a very similar effect to 20 mg/Kg of trideca-7,9,11-trienoic acid. This may suggest that trideca-7,9,11-trienoic acid is also a GABA agonist like diazepam.

Extraction from A. cynapium

Trideca-7,9,11-trienoic acid can be extracted from dried aerial parts of A. cynapium with methanol, followed by chloroform, followed by column chromatography with DCM and methanol (40:60), followed by flash chromatography with DCM and methanol (92.5:7.5), followed by preparative TLC.

References

  1. ^ Shri, Richa; Bhutani, K.K.; Sharma, Anupam (2010). "A new anxiolytic fatty acid from Aethusa cynapium". Fitoterapia. 81 (5): 337–340. doi:10.1016/j.fitote.2010.05.003. (https://www.academia.edu/4694323/A_new_anxiolytic_fatty_acid_from_Aethusa_cynapium)
  2. "(7E,9E,11E)-trideca-7,9,11-trienoic acid". PubChem. National Library of Medicine. 3.1.2025.
  3. EP0503897A1, Gerald Sugarman, Michael W. O'Neill, "Composition for ink vehicles and protective coatings", assigned to Topez Co  16.9.1992.
  4. Bilkei-Gorzo A, Gyertyar I, Szabados T (1996). "mCPP-induced anxiety—a potential new method for screening anxiolytic activity". Neurobiology. 4: 253–5.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Bilkei-Gorzo A, Gyertyar I, Levay G (1998). "mCPP-induced anxiety in the light–dark box in rats—a new method for screening anxiolytic activity". Psychopharmacology. 136: 291–8.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. Riss J, Cloyd J, Gates J, Collins S (August 2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics". Acta Neurologica Scandinavica. 118 (2): 69–86. doi:10.1111/j.1600-0404.2008.01004.x. PMID 18384456. S2CID 24453988.
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