PEG 400: Difference between revisions

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	{\| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
	! {{chembox header}}\| '''Polyethylene glycol''' <!-- replace if not identical with the article name -->
	\|-
	\| align="center" colspan="2" bgcolor="#ffffff" \| ]
	\|-
	\| ]
	\| Polyethylene glycol <!-- replace if not identical with the article name -->
	\|-
	\| ]
⚫	\| C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>, n = 8.2 to 9.1
	\|-
	\| ]
⚫	\| 380-420 g/mol
	\|-
	\| ]
⚫	\|
	\|-
	\| ]
⚫	\| 1.128 g/cm³
	\|-
	\| ]
⚫	\| 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
	\|-
	\| ]
	\| 4-8 °C
	\|-
	\| ]
⚫	\| 238 °C
	\|-
	\| ]
⚫	\| 30 mL/kg, orally in rats
	\|-

			{{Chembox new
			\| Name = Polyethylene glycol
			\| ImageFile = PEG400.gif
			\| ImageName = Polyethylene glycol
			\| IUPACName = Polyethylene glycol
			\| Section1 = {{Chembox Identifiers
		⚫	\| CASNo = 25322-68-3
			}}
			\| Section2 = {{Chembox Properties
		⚫	\| Formula = C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>, n = 8.2 to 9.1
		⚫	\| MolarMass = 380-420 g/mol
		⚫	\| Density = 1.128 g/cm³
		⚫	\| Viscosity = 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
			\| MeltingPt = 4-8 °C
			}}
			\| Section7 = {{Chembox Hazards
		⚫	\| FlashPt = 238 °C
		⚫	\| LD50 = 30 mL/kg, orally in rats
			}}
		⚫	}}

		⚫	'''PEG 400''' (Polyethylene Glycol 400) is a low molecular weight grade of ]. It is a clear, colorless, viscous liqid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

		⚫	==Additional Properties==
	\| {{chembox header}} \| <small>]</small>
		⚫	PEG 400 is strongly ]. The ] of polyethylene glycol 414 between hexane and water is 0.000015 (log<math>P = -4.8</math>), indicating that when polyethylene glycol 414 is mixed with water and hexane, there are only 1.5 parts of polyethylene glycol 414 in the hexane layer per 100,000 parts of polyethylene glycol 414 in the water layer.<ref>{{cite journal
	\|-
		⚫	\| title= PEG 400, a hydrophilic molecular probe for measuring intestinal permeability
⚫	\|}

⚫	'''PEG 400''' (Polyethylene Glycol 400) is a low molecular weight grade of ]. It is a clear, colorless, viscous liqid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.


⚫	== Additional Properties ==
⚫	PEG 400 is strongly ]. The ] of polyethylene glycol 414 between hexane and water is 0.000015 (log <math>P = -4.8</math>), indicating that when polyethylene glycol 414 is mixed with water and hexane, there are only 1.5 parts of polyethylene glycol 414 in the hexane layer per 100,000 parts of polyethylene glycol 414 in the water layer.<ref>{{cite journal
⚫	\| title= PEG 400, a hydrophilic molecular probe for measuring intestinal permeability
	\| author= T. Y. Ma, D. Hollander, P. Krugliak, K. Katz		\| author= T. Y. Ma, D. Hollander, P. Krugliak, K. Katz
	\| journal= Gastroenterology		\| journal= Gastroenterology
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	\| issue= 1		\| issue= 1
	\| pages= 39-46		\| pages= 39-46
	\| year= 1990		\| year= 1990
	\| url= http://www.gastrojournal.org/article/PII001650859091288H/abstract}}</ref>		\| url= http://www.gastrojournal.org/article/PII001650859091288H/abstract}}</ref>

	PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.		PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.

	== References ==		==References==
	{{reflist}}		{{reflist}}

Revision as of 05:06, 13 January 2008

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Template:Chembox new

PEG 400 (Polyethylene Glycol 400) is a low molecular weight grade of Polyethylene glycol. It is a clear, colorless, viscous liqid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

Additional Properties

PEG 400 is strongly hydrophilic. The partition coefficient of polyethylene glycol 414 between hexane and water is 0.000015 (log $P=-4.8$ ), indicating that when polyethylene glycol 414 is mixed with water and hexane, there are only 1.5 parts of polyethylene glycol 414 in the hexane layer per 100,000 parts of polyethylene glycol 414 in the water layer.

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.

References

T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46.{{cite journal}}: CS1 maint: multiple names: authors list (link)

The Merck Index, 11th Edition
Handbook of Pharmaceutical Excipients

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