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'''Duloxetine hydrochloride''' (brand name: '''Cymbalta''') is a medically used drug that primarily targets major ] disorders (MDD), pain related to ] ] and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. '''Duloxetine hydrochloride''' (brand name: '''Cymbalta'''/'''Yentreve''') is a medically used drug that primarily targets major ] disorders (MDD), pain related to ] ] and stress ] (SUI). Known also as LY248686, chemically (+)-(''S'')-''N''-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of ] (5-hydroxytryptamine, 5-HT) and ] (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.


Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours. Furthermore, duloxentine lacks affinity for ] ] within the ]. While there is limited data available regarding the ] profile of duloxetine in humans, its ] is reported to be 10 to 15 hours.

Revision as of 09:18, 19 October 2005

Duloxetine chemical structure of duloxetine
Duloxetine

IUPAC chemical name
CAS number
 ? 		ATC code
 ?
Chemical formula C18H19NOS, HCl
Molecular weight 333.38
Bioavailability ?
Metabolism Hepatic Oxidation
Elimination half-life 8-17 hours
Excretion 70% in urine, 20% in feces
Pregnancy category C (USA)
Legal status Prescription only (USA)
Routes of administration Oral

Duloxetine hydrochloride (brand name: Cymbalta/Yentreve) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.

Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.

Duloxentine is also approved by the FDA for the treatment of diabetic neuropathy.

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