|
'''U46619''' is a stable synthetic ] of the ] PGH<sub>2</sub> first prepared in 1975.<ref>{{cite journal | author = Bundy, G. L. | title = Synthesis of prostaglandin endoperoxide analogs | journal = Tetrahedron Letters | year = 1975 | volume = 24 | pages = 1957–1960 | doi = 10.1016/S0040-4039(00)72333-1}}</ref> U46619 is a ] that mimics the hydroosmotic effect of ].<ref>{{cite journal | title = Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport | author = Burch, Ronald M.; Halushka, Perry V. | journal = Journal of Pharmacology and Experimental Therapeutics |year=1983|volume =224|issue=1|pages= 108–17 | pmid = 6294273}}</ref> It also mimics the effects of ] by activating ].<ref>{{cite journal | title = Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP | author = Rittenhouse, Susan E. | journal = Biochemical Journal |year=1984 | volume = 222 | issue = 1 | pages = 103–110 | pmid = 6433894 | pmc = 1144149}}</ref> <ref>{{cite article|title=Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697|author=Michael P. Walsh, et all|url=http://biosupport.licor.com/docs/2005/BJ20050237.pdf}} </ref> |
|
'''U46619''' is a stable synthetic ] of the ] PGH<sub>2</sub> first prepared in 1975.<ref>{{cite journal | author = Bundy, G. L. | title = Synthesis of prostaglandin endoperoxide analogs | journal = Tetrahedron Letters | year = 1975 | volume = 24 | pages = 1957–1960 | doi = 10.1016/S0040-4039(00)72333-1}}</ref> U46619 is a ] that mimics the hydroosmotic effect of ].<ref>{{cite journal | title = Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport | author = Burch, Ronald M.; Halushka, Perry V. | journal = Journal of Pharmacology and Experimental Therapeutics |year=1983|volume =224|issue=1|pages= 108–17 | pmid = 6294273}}</ref> It also mimics the effects of ] by activating ].<ref>{{cite journal | title = Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP | author = Rittenhouse, Susan E. | journal = Biochemical Journal |year=1984 | volume = 222 | issue = 1 | pages = 103–110 | pmid = 6433894 | pmc = 1144149}}</ref><ref>{{cite journal|title=Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697|author=Michael P. Walsh, et all|url=http://biosupport.licor.com/docs/2005/BJ20050237.pdf}}</ref> |
