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'''Iodophenpropit''' is a ] which binds selectively to the ] subtype. Its <sup>125</sup>I ] form is used for mapping the distribution of H<sub>3</sub> receptors in the body.<ref>{{cite journal | pmid = 7834183 }}</ref><ref>{{cite journal | pmid = 10935534 }}</ref> '''Iodophenpropit''' is a ] which binds selectively to the ] subtype. Its <sup>125</sup>I ] form is used for mapping the distribution of H<sub>3</sub> receptors in the body.<ref>{{cite journal | last1 = Jansen | first1 = FP | last2 = Wu | first2 = TS | last3 = Voss | first3 = HP | last4 = Steinbusch | first4 = HW | last5 = Vollinga | first5 = RC | last6 = Rademaker | first6 = B | last7 = Bast | first7 = A | last8 = Timmerman | first8 = H | title = Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain | journal = British journal of pharmacology | volume = 113 | issue = 2 | pages = 355–62 | year = 1994 | pmid = 7834183 | pmc = 1510107 }}</ref><ref>{{cite journal | last1 = Jansen | first1 = FP | last2 = Mochizuki | first2 = T | last3 = Maeyama | first3 = K | last4 = Leurs | first4 = R | last5 = Timmerman | first5 = H | title = Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit | journal = Naunyn-Schmiedeberg's archives of pharmacology | volume = 362 | issue = 1 | pages = 60–7 | year = 2000 | pmid = 10935534 }}</ref>


==References== ==References==

Revision as of 23:30, 5 December 2010

Iodophenpropit
Names
IUPAC name 3-(1H-imidazol-5-yl)propyl N'-imidothiocarbamate
Other names 1--N'-formamidine
Identifiers
CAS Number
3D model (JSmol)
MeSH Iodophenpropit
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
Properties
Chemical formula C15H19IN4S
Molar mass 414.30763
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype. Its I radiolabelled form is used for mapping the distribution of H3 receptors in the body.

References

  1. Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British journal of pharmacology. 113 (2): 355–62. PMC 1510107. PMID 7834183.
  2. Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's archives of pharmacology. 362 (1): 60–7. PMID 10935534.
Histamine receptor modulators
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
See also
Receptor/signaling modulators
Monoamine metabolism modulators
Monoamine reuptake inhibitors


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