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Revision as of 20:33, 19 April 2011

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FV-100
Names
IUPAC name 3--6-(4-pentylphenyl)furopyrimidin-2-one
Other names Cf1743
Identifiers
3D model (JSmol)
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • CCCCCC1=CC=C(C=C1)C2=CC3=CN(C(=O)N=C3O2)4C((O4)CO)O
Properties
Chemical formula C22H26N2O5
Molar mass 398.459 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

FV-100, also known as Cf1743, is an orally available nucleoside analogue drug with antiviral activity. It may be effective against shingles.

It was discovered in 1999.

Clinical trials

It is in a phase II trial against valaciclovir in patients with herpes zoster.

References

  1. Inhibitex Completes Phase I Clinical Trials For FV-100 And Selects Lead HCV Compounds For Advanced Preclinical Studies, 2009
  2. McGuigan, Christopher; Balzarini, Jan (2009). "FV100 as a new approach for the possible treatment of varicella-zoster virus infection". Journal of Antimicrobial Chemotherapy. 64 (4): 671–673. doi:10.1093/jac/dkp294. PMID 19679595.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. , 2010 http://www.dailymail.co.uk/health/article-515969/Thousands-spared-pain-shingles.html, And at Cardiff University, Chris McGuigan, professor of medicinal chemistry, has developed a new drug for shingles, FV-100, which is doing well in phase I trials. FV 100 looks like it will be very potent (more than 10,000 times as strong as aciclovir), safe and could prevent long-term pain, too. It could be on the market by 2010. {{citation}}: Missing or empty |title= (help)
  4. Step forward for shingles drug - FV100 Shows structure of FV100
  5. A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster


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