Tolciclate: Difference between revisions

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Revision as of 09:55, 14 August 2011 editCheMoBot (talk \| contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation ← Previous edit		Revision as of 13:05, 3 September 2011 edit undoBogBot (talk \| contribs)Bots53,132 edits populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBot Next edit →
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	{{~~drugbox~~		{{Drugbox
⚫	\| UNII_Ref = {{fdacite\|correct\|FDA}}
⚫	\| UNII = T3TZ02X2AZ
	\| verifiedrevid = 443448273		\| verifiedrevid = 443448273
	\| IUPAC_name =		\| IUPAC_name =
	\| image = tolciclate.png		\| image = tolciclate.png

⚫	\| CAS_number = 50838-36-3
			<!--Clinical data-->
⚫	\| ATC_prefix = D01
	\| ~~ATC_suffix~~ = ~~AE19~~		\| tradename =
			\| Drugs.com = {{drugs.com\|international\|tolciclate}}
⚫	\| PubChem = 5506
		⚫	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
		⚫	\| pregnancy_US = <!-- A / B / C / D / X -->
		⚫	\| pregnancy_category =
		⚫	\| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
		⚫	\| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
		⚫	\| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
		⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
		⚫	\| legal_status =
		⚫	\| routes_of_administration =

			<!--Pharmacokinetic data-->
		⚫	\| bioavailability =
		⚫	\| protein_bound =
		⚫	\| metabolism =
		⚫	\| elimination_half-life =
		⚫	\| excretion =

			<!--Identifiers-->
		⚫	\| CAS_number = 50838-36-3
		⚫	\| ATC_prefix = D01
			\| ATC_suffix = AE19
		⚫	\| PubChem = 5506
	\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}		\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
	\| DrugBank =		\| DrugBank =
		⚫	\| UNII_Ref = {{fdacite\|correct\|FDA}}
		⚫	\| UNII = T3TZ02X2AZ
	\| KEGG_Ref = {{keggcite\|correct\|kegg}}		\| KEGG_Ref = {{keggcite\|correct\|kegg}}
	\| KEGG = D01384		\| KEGG = D01384

⚫	\| C=20\|H=21\|N=1\|O=1\|S=1
			<!--Chemical data-->
⚫	\| molecular_weight = 323.45 g/mol
		⚫	\| C=20 \| H=21 \| N=1 \| O=1 \| S=1
⚫	\| bioavailability =
		⚫	\| molecular_weight = 323.45 g/mol
⚫	\| protein_bound =
⚫	\| metabolism =
⚫	\| elimination_half-life =
⚫	\| excretion =
⚫	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫	\| pregnancy_US = <!-- A / B / C / D / X -->
⚫	\| pregnancy_category=
⚫	\| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫	\| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫	\| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫	\| legal_status =
⚫	\| routes_of_administration =
	}}		}}

Revision as of 13:05, 3 September 2011

Pharmaceutical compound

Tolciclate
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	D01AE19 (WHO)
Identifiers
CAS Number	50838-36-3
PubChem CID	5506
UNII	T3TZ02X2AZ
KEGG	D01384
CompTox Dashboard (EPA)	DTXSID0057758
ECHA InfoCard	100.051.611
Chemical and physical data
Formula	C₂₀H₂₁NOS
Molar mass	323.45 g/mol g·mol
(verify)

Tolciclate is an antifungal.

References

Ryder NS, Frank I, Dupont MC (1986). "Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate". Antimicrob. Agents Chemother. 29 (5): 858–60. PMC 284167. PMID 3524433. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Bianchi A, Monti G, de Carneri I (1977). "Tolciclate: further antimycotic studies". Antimicrob. Agents Chemother. 12 (3): 429–30. PMC 429931. PMID 907333. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles (lanosterol 14α-
demethylase inhibitors)

Imidazoles

Systemic: ketoconazole

Triazoles

Unknown: albaconazole
ravuconazole

Thiazoles

Topical: abafungin

Polyene antimycotics
(ergosterol binding)

Topical: hamycin
natamycin
nystatin
Systemic: amphotericin B, hamycin

Squalene monooxygenase
inhibitors

Allylamines	Topical: naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical: butenafine

Others

Topical: amorolfine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	Systemic: flucytosine
Mitotic inhibitors	Systemic: griseofulvin
Aminoacyl tRNA synthetase inhibitors	Topical: tavaborole

Others

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

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