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Anecortave acetate: Difference between revisions

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| ATC_prefix = S01 | ATC_prefix = S01
| ATC_suffix = LA02 | ATC_suffix = LA02
| PubChem = 111332 | PubChem = 111332
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| DrugBank = ? | DrugBank = <!-- blanked - oldvalue: ? -->
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Revision as of 11:21, 24 October 2011

Pharmaceutical compound
Anecortave acetate
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • ?
Routes of
administration		intravitreal depot injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability?
Metabolism?
Elimination half-life?
Excretion?
Identifiers
IUPAC name
  • phenanthren-17-yl]-
    2-oxo-ethyl] acetate
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.028.920 Edit this at Wikidata
Chemical and physical data
FormulaC23H30O5
Molar mass386.48 g·mol
3D model (JSmol)
SMILES
  • O=C(OCC(=O)1(O)CC24/C(=C\C12C)3(/C(=C\C(=O)CC3)CC4)C)C
InChI
  • InChI=1S/C23H30O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h7,12,17,19,27H,4-6,8-11,13H2,1-3H3/t17-,19+,21+,22+,23+/m1/s1
  • Key:YUWPMEXLKGOSBF-GACAOOTBSA-N
  (verify)

Anecortave (rINN) (/ænəˈkɔːrteɪv/) is a novel angiogenesis inhibitor used in the treatment of the exudative (wet) form of age-related macular degeneration. Although based on a steroid nucleus, it possesses little glucocorticoid activity. It will be marketed by Alcon as anecortave acetate for depot suspension under the trade name Retaane.

Synthesis

Anecortave can be synthesized from a 17-oxosteroid:

References

  1. J.G. Reid, T. Debiak-Krook (1990). "Corticoids from 17-oxosteroids". Tetrahedron Lett. 31: 3669. doi:10.1016/S0040-4039(00)97440-9.


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Ophthalmologicals: ocular vascular disorder agents (S01L)
Antineovascularisation agents
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