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'''Coptisine''' is an ] found in Chinese goldthread ('']'').<ref></ref> Famous for the bitter taste that it produces, it is used in ] along with the related compound ] for treating digestive disorders caused by bacterial infections. '''Coptisine''' is an ] found in Chinese goldthread ('']'').<ref>{{MEDRS}}</ref> Famous for the bitter taste that it produces, it is used in ] along with the related compound ] for treating digestive disorders caused by bacterial infections.{{fact}}


Also found in ] and has also been detected in ].<ref>Hakim et al., 1961</ref> {{Fact|date=September 2008}} Also found in ] and has also been detected in ].<ref>{{cite journal |pmid=13710637}}</ref>


Coptisine has been found to reversibly inhibit ] in mice, pointing to a potential role as a natural antidepressant<ref></ref>. However, this may also imply a hazard for those taking other medications or with a natural functional disorder in Monoamine oxidase A. Coptisine has been found to reversibly inhibit ] in mice, pointing to a potential role as a natural antidepressant.<ref>{{cite journal |pmid=11833714}}</ref> However, this may also imply a hazard for those taking other medications or with a natural functional disorder in Monoamine oxidase A.{{fact}}


Coptisine was found to be toxic to larval ] and a variety of human cell lines, potentially implying a therapeutic effect on cancer or alternatively a generally toxic character. The same authors illustrate a four-step process to produce Coptisine from ]<ref></ref>. Coptisine was found to be toxic to larval ] and a variety of human cell lines, potentially implying a therapeutic effect on cancer or alternatively a generally toxic character. The same authors illustrate a four-step process to produce Coptisine from ].<ref>{{cite journal |pmid=11482767}}</ref>


==Footnotes== ==Footnotes==

Revision as of 18:10, 21 November 2011

Coptisine
Names
IUPAC name 6,7-Dihydro-bis(1,3)benzodioxolo (5,6-a:4',5'-g)quinolizinium
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1Key: XYHOBCMEDLZUMP-UHFFFAOYSA-N
  • InChI=1/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1Key: XYHOBCMEDLZUMP-UHFFFAOYAS
SMILES
  • O1c3c(OC1)c2c6c(cc2cc3)c5cc4OCOc4cc5CC6
Properties
Chemical formula C19H14NO4+
Molar mass 320.319
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). Famous for the bitter taste that it produces, it is used in Chinese herbal medicine along with the related compound berberine for treating digestive disorders caused by bacterial infections.

Also found in Greater Celandine and has also been detected in Opium.

Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant. However, this may also imply a hazard for those taking other medications or with a natural functional disorder in Monoamine oxidase A.

Coptisine was found to be toxic to larval brine shrimp and a variety of human cell lines, potentially implying a therapeutic effect on cancer or alternatively a generally toxic character. The same authors illustrate a four-step process to produce Coptisine from Berberine.

Footnotes

  1. Complementary and Alternative Healing University (Chinese Medicine)
  2. . PMID 13710637. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. . PMID 11833714. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. . PMID 11482767. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)


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