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Revision as of 13:07, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 458393435 of page Piminodine for the Chem/Drugbox validation project (updated: 'CAS_number').← Previous edit Revision as of 13:08, 5 December 2011 edit undoBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 457076302 of page Pimozide for the Chem/Drugbox validation project (updated: '').Next edit →
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} {{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{Drugbox {{drugbox
| Verifiedfields = changed
⚫ | verifiedrevid = 447990189
| Watchedfields = changed
| IUPAC_name = ethyl 1-(3-anilinopropyl)-4-phenylpiperidine-4-carboxylate
⚫ | verifiedrevid = 419225254
⚫ | image = Piminodine.svg
| IUPAC_name = 1--<BR>4-piperidinyl]-1,3-dihydro-<BR>2''H''-benzimidazole-2-one
⚫ | width = 160
⚫ | image = Pimozide skeletal.svg
⚫ | width = 300


<!--Clinical data--> <!--Clinical data-->
| tradename = | tradename = Orap
| Drugs.com = {{drugs.com|monograph|pimozide}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| MedlinePlus = a686018
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = Teratogenic data in rats exist : drug should only be used when the benefit clearly exceeds the potential harm to the unborn
| pregnancy_category =
| legal_status = Rx-only, not a controlled narcotic
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | routes_of_administration = oral only
| legal_CA = <!-- Schedule I -->
| legal_UK = <!-- Class A -->
| legal_US = Schedule II
| legal_status =
⚫ | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
| bioavailability = | bioavailability = at least 40 to 50%
| metabolism = hepatic, by cytochrome P450, isoenzymes 3A, and 1A2; metabolites are inactive
| protein_bound =
| elimination_half-life = 2 to 3 days (average in one study 55 hours)
| metabolism =
| excretion = urine, and to a lesser extent in feces
| elimination_half-life =
| excretion =


<!--Identifiers--> <!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}} | CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = <!-- blanked - oldvalue: 13495-09-5 --> | CAS_number = 2062-78-4
| ATC_prefix = none | ATC_prefix = N05
| ATC_suffix = | ATC_suffix = AG02
| PubChem = 21950 | PubChem = 16362
| IUPHAR_ligand = 90
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = | DrugBank = DB01100
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 20628 | ChemSpiderID = 15520
| UNII_Ref = {{fdacite|correct|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3IIX447HWS | UNII = 1HIZ4DL86F
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00560
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 8212
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1423


<!--Chemical data--> <!--Chemical data-->
| C=23 | H=30 | N=2 | O=2 | C=28 | H=29 | F=2 | N=3 | O=1
| molecular_weight = 366.497 g/mol | molecular_weight = 461.56
| smiles = O=C(OCC)C3(c1ccccc1)CCN(CCCNc2ccccc2)CC3 | smiles = Fc1ccc(cc1)C(c2ccc(F)cc2)CCCN5CCC(N4c3ccccc3NC4=O)CC5
| InChI = 1/C23H30N2O2/c1-2-27-22(26)23(20-10-5-3-6-11-20)14-18-25(19-15-23)17-9-16-24-21-12-7-4-8-13-21/h3-8,10-13,24H,2,9,14-19H2,1H3 | InChI = 1/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
| InChIKey = PXXKIYPSXYFATG-UHFFFAOYAI
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C23H30N2O2/c1-2-27-22(26)23(20-10-5-3-6-11-20)14-18-25(19-15-23)17-9-16-24-21-12-7-4-8-13-21/h3-8,10-13,24H,2,9,14-19H2,1H3 | StdInChI = 1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PXXKIYPSXYFATG-UHFFFAOYSA-N | StdInChIKey = YVUQSNJEYSNKRX-UHFFFAOYSA-N
| synonyms =
}} }}

Revision as of 13:08, 5 December 2011

This page contains a copy of the infobox ({{drugbox}}) taken from revid 457076302 of page Pimozide with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
Trade namesOrap
AHFS/Drugs.comMonograph
MedlinePlusa686018
Pregnancy
category
  • Teratogenic data in rats exist : drug should only be used when the benefit clearly exceeds the potential harm to the unborn
Routes of
administration		oral only
ATC code
Legal status
Legal status
  • Rx-only, not a controlled narcotic
Pharmacokinetic data
Bioavailabilityat least 40 to 50%
Metabolismhepatic, by cytochrome P450, isoenzymes 3A, and 1A2; metabolites are inactive
Elimination half-life2 to 3 days (average in one study 55 hours)
Excretionurine, and to a lesser extent in feces
Identifiers
IUPAC name
  • 1--
    4-piperidinyl]-1,3-dihydro-
    2H-benzimidazole-2-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC28H29F2N3O
Molar mass461.56 g·mol
3D model (JSmol)
SMILES
  • Fc1ccc(cc1)C(c2ccc(F)cc2)CCCN5CCC(N4c3ccccc3NC4=O)CC5
InChI
  • InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
  • Key:YVUQSNJEYSNKRX-UHFFFAOYSA-N
  (what is this?)  (verify)