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| {{DiseaseDisorder infobox | | {{DiseaseDisorder infobox | | ||
| Name = Myopathy | | |||
| ICD10 = G71-G72 | | |||
| ICD9 = {{ICD9|359.4}}-{{ICD9|359.9}} | | |||
| }} | }} | ||
| In ], a '''myopathy''' is a neuromuscular ] in which the ]s dysfunction for any one of many reasons, resulting in ]. "Myopathy" simply means disorder ("pathy" from pathology) of muscle ("myo"). |
In ], a '''myopathy''' is a neuromuscular ] in which the ]s dysfunction for any one of many reasons, resulting in ]. "Myopathy" simply means disorder ("pathy" from pathology) of muscle ("myo"). This implies that the primary defect is within the muscle, as opposed to the nerves ("]" or "]" disorders) or elsewhere (e.g., the brain etc.). ]s, ], and ] can also be associated with myopathy. | ||
| ==Classes== | ==Classes== | ||
| Because myopathy is such a general term, there are several classes of myopathy. (] codes are provided where available.) | Because myopathy is such a general term, there are several classes of myopathy. (] codes are provided where available.) | ||
| ⚫ | * (G71.0) ] (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, since the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a ], and eventually death, usually related to ]. | ||
| ⚫ | * (G71.0) ] (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. |
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| * (G71.1) ] | * (G71.1) ] | ||
| ** ] | ** ] | ||
| * (G71.2) The ] do not show evidence for either a progressive dystrophic process (i.e., muscle death) or |
* (G71.2) The ] do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Among others, different congenital myopathies include: | ||
| ** (G71.2) ] (characterized by presence of "nemaline rods" in the muscle), | ** (G71.2) ] (characterized by presence of "nemaline rods" in the muscle), | ||
| ** (G71.2) ] (characterized by multiple small "cores" or areas of disruption in the muscle fibers), | ** (G71.2) ] (characterized by multiple small "cores" or areas of disruption in the muscle fibers), | ||
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| * (G71.3) ] are due to defects in ], which provide a critical source of energy for muscle. | * (G71.3) ] are due to defects in ], which provide a critical source of energy for muscle. | ||
| * (G72.3) ] | * (G72.3) ] | ||
| * (G72.4) ] are caused by problems with the immune system attacking components of the muscle, leading to signs of ] in the muscle. |
* (G72.4) ] are caused by problems with the immune system attacking components of the muscle, leading to signs of ] in the muscle. | ||
| * (G73.6) ] result from defects in biochemical metabolism that primarily affect muscle | * (G73.6) ] result from defects in biochemical metabolism that primarily affect muscle | ||
| ** (G73.6/E74.0) ]s may affect muscle | ** (G73.6/E74.0) ]s may affect muscle | ||
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| Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptomes to very specific cause-targeting treatments. ], ], bracing for support, ], and even ] are current treatments for a variety of myopathies. | Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptomes to very specific cause-targeting treatments. ], ], bracing for support, ], and even ] are current treatments for a variety of myopathies. | ||
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Revision as of 17:08, 17 April 2006
Medical condition| Myopathy | |
|---|---|
| Specialty | Rheumatology  |
In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. "Myopathy" simply means disorder ("pathy" from pathology) of muscle ("myo"). This implies that the primary defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the brain etc.). Muscle cramps, stiffness, and spasm can also be associated with myopathy.
Classes
Because myopathy is such a general term, there are several classes of myopathy. (ICD-10 codes are provided where available.)
- (G71.0) Dystrophies (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, since the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a wheelchair, and eventually death, usually related to respiratory weakness.
- (G71.1) Myotonia
- (G71.2) The congenital myopathies do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Among others, different congenital myopathies include:
- (G71.2) nemaline myopathy (characterized by presence of "nemaline rods" in the muscle),
- (G71.2) multi/minicore myopathy (characterized by multiple small "cores" or areas of disruption in the muscle fibers),
- (G71.2) Centronuclear myopathy (or myotubular mypathy) (in which the nuclei are abnormally found in the center of the muscle fibers) is a rare muscle wasting disorder that occurs in three forms:
- The most severe form is present at birth, inherited as an X-linked genetic trait, and can cause severe respiratory muscle weakness.
- A less severe form of myotubular myopathy that may present itself at birth or in early childhood progresses slowly and is inherited as an autosomal recessive genetic trait.
- The least severe of the three forms of myotubular myopathy first appears during the first and third decades of life and is slowly progressive; it is inherited as an autosomal dominant genetic trait.
- (G71.3) Mitochondrial myopathies are due to defects in mitochondria, which provide a critical source of energy for muscle.
- (G72.3) Familial periodic paralysis
- (G72.4) Inflammatory myopathies are caused by problems with the immune system attacking components of the muscle, leading to signs of inflammation in the muscle.
- (G73.6) Metabolic myopathies result from defects in biochemical metabolism that primarily affect muscle
- (G73.6/E74.0) Glycogen storage diseases may affect muscle
- (G73.6/E75) Lipid storage disorder
- (M33.0-M33.1) Dermatomyositis, (M33.2) polymyositis, inclusion body myositis, and related myopathies
- (M61) Myositis ossificans
- (M62.89) Rhabdomyolysis and (R82.1) myoglobinurias
- Common muscle (R25.2) cramps and (M25.6) stiffness, and (R29.0) tetany
Treatments
Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptomes to very specific cause-targeting treatments. Drug therapy, physical therapy, bracing for support, surgery, and even acupuncture are current treatments for a variety of myopathies.
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