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'''Trolox''' is ]'s trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a water-soluble derivative of ]. It is an ], like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage. '''Trolox''' is ]'s trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a water-soluble derivative of ]. It is an ], like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage.


] (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ] decolorization assay.<ref>Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237</ref> Other measures include ] (ORAC) and ] (FRAP).The TEAC assay is often used to measure the antioxidant capacity of foods, beverages and nutritional supplements. ] (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ] decolorization assay.<ref>Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237</ref> An alternative measurement is the ] (FRAP). The TEAC assay is used to measure antioxidant capacity of foods, beverages and supplements.

] (ORAC) used to be an alternative measurement, but the ] (USDA) withdrew these ratings in 2012 as biologically invalid, stating that no physiological proof '']'' existed to support the ].<ref name=USDAx>{{cite web |url=http://www.ars.usda.gov/services/docs.htm?docid=15866 |title=Withdrawn: Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release 2 (2010) |author= |date=16 May 2012 |work= |publisher=United States Department of Agriculture, Agricultural Research Service |accessdate=13 June 2012}}</ref>


==Notes== ==Notes==
{{reflist}} {{reflist|colwidth=30em}}


] ]

Revision as of 23:45, 15 December 2012

Trolox
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ECHA InfoCard 100.053.094 Edit this at Wikidata
PubChem CID
CompTox Dashboard (EPA)
SMILES
  • CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O
Properties
Chemical formula C14H18O4
Molar mass 250.294 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Trolox is Hoffman-LaRoche's trade name for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a water-soluble derivative of vitamin E. It is an antioxidant, like vitamin E, and is used in biological or biochemical applications to reduce oxidative stress or damage.

Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ABTS decolorization assay. An alternative measurement is the ferric reducing ability of plasma (FRAP). The TEAC assay is used to measure antioxidant capacity of foods, beverages and supplements.

Oxygen radical absorbance capacity (ORAC) used to be an alternative measurement, but the United States Department of Agriculture (USDA) withdrew these ratings in 2012 as biologically invalid, stating that no physiological proof in vivo existed to support the free-radical theory.

Notes

  1. Re, R.; Pellegrini, N.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237
  2. "Withdrawn: Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release 2 (2010)". United States Department of Agriculture, Agricultural Research Service. 16 May 2012. Retrieved 13 June 2012.
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