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==Pathology== |
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==Pathology== |
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] of a brown tumor (left of image). ].]] |
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] of a brown tumor (left of image). ].]] |
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Brown tumours consist of ], woven bone and supporting ], but no ]. The osteoclasts consume the ] that ] lay down and this front of reparative bone deposition followed by additional resorption can expand beyond the usual shape of the bone, involving the ] thus causing bone pain. The characteristic brown coloration results from ] deposition into the osteolytic cysts. Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen ].<ref name=pmid1939753>{{Cite journal | last1 = Aoki | first1 = J. | last2 = Moriya | first2 = K. | last3 = Yamashita | first3 = K. | last4 = Fujioka | first4 = F. | last5 = Ishii | first5 = K. | last6 = Karakida | first6 = O. | last7 = Imai | first7 = S. | last8 = Sakai | first8 = F. | last9 = Imai | first9 = Y. | last10 = Sone | first10 = S | title = Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation | journal = J Comput Assist Tomogr | volume = 15 | issue = 6 | pages = 1024–7 | year = 1991| doi = | pmid = 1939753 | display-authors = 8 }}</ref><ref name=pmid18554912>{{Cite journal | last1 = Matsushige | first1 = T. | last2 = Nakaoka | first2 = M. | last3 = Yahara | first3 = K. | last4 = Kagawa | first4 = K. | last5 = Miura | first5 = H. | last6 = Ohnuma | first6 = H. | last7 = Kurisu | first7 = K. | title = Giant cell tumor of the temporal bone with intratumoral hemorrhage | journal = J Clin Neurosci | volume = 15 | issue = 8 | pages = 923–7 |date=Aug 2008 | doi = 10.1016/j.jocn.2007.03.013 | pmid = 18554912 }}</ref> |
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Brown tumours consist of ], woven bone and supporting ], but no ]. The osteoclasts consume the ] that ] lay down and this front of reparative bone deposition followed by additional resorption can expand beyond the usual shape of the bone, involving the ] thus causing bone pain. The characteristic brown coloration results from ] deposition into the osteolytic cysts. Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen ].<ref name=pmid1939753>{{Cite journal | last1 = Aoki | first1 = J. | last2 = Moriya | first2 = K. | last3 = Yamashita | first3 = K. | last4 = Fujioka | first4 = F. | last5 = Ishii | first5 = K. | last6 = Karakida | first6 = O. | last7 = Imai | first7 = S. | last8 = Sakai | first8 = F. | last9 = Imai | first9 = Y. | last10 = Sone | first10 = S | title = Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation | journal = J Comput Assist Tomogr | volume = 15 | issue = 6 | pages = 1024–7 | year = 1991| doi = 10.1097/00004728-199111000-00023| pmid = 1939753 | display-authors = 8 }}</ref><ref name=pmid18554912>{{Cite journal | last1 = Matsushige | first1 = T. | last2 = Nakaoka | first2 = M. | last3 = Yahara | first3 = K. | last4 = Kagawa | first4 = K. | last5 = Miura | first5 = H. | last6 = Ohnuma | first6 = H. | last7 = Kurisu | first7 = K. | title = Giant cell tumor of the temporal bone with intratumoral hemorrhage | journal = J Clin Neurosci | volume = 15 | issue = 8 | pages = 923–7 |date=Aug 2008 | doi = 10.1016/j.jocn.2007.03.013 | pmid = 18554912 }}</ref> |
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Brown tumors may be rarely associated with ectopic parathyroid adenomas.<ref>{{cite journal|last=Sharma|first=Ravi|author2=Mathan Mohan|author3=R S Neelakandan|author4=D Siddharth|title=An unusual case of brown tumor of hyperparathyroidism associated with ectopic parathyroid adenoma|journal=European Journal of Dentistry|date=October 2013|volume=7|issue=4|pages=500–503|doi=10.4103/1305-7456.120657|url=http://www.eurjdent.com/text.asp?2013/7/4/500/120657|accessdate=2013-10-28}}</ref> |
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Brown tumors may be rarely associated with ectopic parathyroid adenomas.<ref>{{cite journal|last=Sharma|first=Ravi|author2=Mathan Mohan|author3=R S Neelakandan|author4=D Siddharth|title=An unusual case of brown tumor of hyperparathyroidism associated with ectopic parathyroid adenoma|journal=European Journal of Dentistry|date=October 2013|volume=7|issue=4|pages=500–503|doi=10.4103/1305-7456.120657|url=http://www.eurjdent.com/text.asp?2013/7/4/500/120657|accessdate=2013-10-28}}</ref> |
Brown tumors may be rarely associated with ectopic parathyroid adenomas.