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| This result was demonstrated in a ] known as the Lifestyle Heart Trial, with data published in ] in 1990, which recruited test subjects with pre-existing coronary artery disease. Not only did patients assigned to the above regimen fare better with respect to cardiac events than those who followed standard medical advice, their coronary ] was somewhat reversed, as evidenced by decreased ] (narrowing) of the ] after one year of treatment. Most patients in the control group, by contrast, had narrower coronary arteries at the end of the trial than the start. | This result was demonstrated in a ] known as the Lifestyle Heart Trial, with data published in ] in 1990, which recruited test subjects with pre-existing coronary artery disease. Not only did patients assigned to the above regimen fare better with respect to cardiac events than those who followed standard medical advice, their coronary ] was somewhat reversed, as evidenced by decreased ] (narrowing) of the ] after one year of treatment. Most patients in the control group, by contrast, had narrower coronary arteries at the end of the trial than the start. | ||
| This discovery was notable not only because it had seemed physiologically implausible, but because it suggested a cheaper and safer weapon against cardiovascular disease than invasive procedures such as ]. | This discovery was notable not only because it had seemed physiologically implausible, but also because it suggested a cheaper and safer weapon against cardiovascular disease than invasive procedures such as ]. | ||
| == External links == | == External links == | ||
Revision as of 23:11, 30 June 2006
Dr. Dean Ornish is president and founder of the Preventive Medicine Research Institute in Sausalito, California, as well as Clinical Professor of Medicine at the University of California, San Francisco.
Dr. Ornish is widely known for his lifestyle-driven approach to the control of coronary artery disease (CAD). Dr. Ornish and colleagues showed that a lifestyle regimen featuring meditation, a low-fat vegetarian diet, smoking cessation, and regular exercise could not only stop the progression of CAD, but could actually reverse its course.
This result was demonstrated in a randomized controlled trial known as the Lifestyle Heart Trial, with data published in the Lancet in 1990, which recruited test subjects with pre-existing coronary artery disease. Not only did patients assigned to the above regimen fare better with respect to cardiac events than those who followed standard medical advice, their coronary atherosclerosis was somewhat reversed, as evidenced by decreased stenosis (narrowing) of the coronary arteries after one year of treatment. Most patients in the control group, by contrast, had narrower coronary arteries at the end of the trial than the start.
This discovery was notable not only because it had seemed physiologically implausible, but also because it suggested a cheaper and safer weapon against cardiovascular disease than invasive procedures such as coronary artery bypass surgery.
External links
References
- Ornish, D et al (1990). Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet Jul 21;336(8708):129-33.
- Ornish, D., Scherwitz, L. W., Doody, R. S., Kesten, D., McLanahan, S. M., Brown, S. E. et al: Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA, 249: 54, 1983
- Ornish, D., Scherwitz, L. W., Billings, J. H., Brown, S. E., Gould, K. L., Merritt, T. A. et al: Intensive lifestyle changes for reversal of coronary heart disease. JAMA, 280: 2001, 1998
- Dunn-Emke, S., Weidner, G., Pettengill, E., Marlin, R. O., Chi, C. and Ornish, D.: Nutritional adequacy of a very low-fat vegan diet. J Am Diet Assoc, 105: 1350, 2005
- Ornish, D.: Intensive lifestyle changes in management of coronary heart disease. In: Harrison's Advances in Cardiology. Edited by E. Braunwald. New York: McGraw-Hill, 2002
- Sumner, Michael D. PhD 1; Weidner, Gerdi PhD 1; Merritt-Worden, Terri MS 2; Studley, Joli MS 2; Ornish, Dean MDF 1 ADHERENCE TO A MULTICOMPONENT LIFESTYLE MODIFICATION PROGRAM. Journal of Cardiopulmonary Rehabilitation. 25(5):291, September/October 2005.
- Ornish, Dean High-Fiber Diet and Colorectal Adenomas. New England Journal of Medicine. 343(10):736-738, September 7, 2000.
- Ornish, Dean; Brown, Shirley Elizabeth; Kottke, Bruce A.; Shea, Steven; Barth, Jacques D.; Bryan, Gregory K.; Hokanson, John E.; Austin, Melissa A.; Ginsberg, Henry N.; Tall, Alan R.; Deckelbaum, Richard J.; Hunninghake, Donald B.; Criqui, Michael H.; Heiss, Gerardo; Sox, Harold C. Treatment Of And Screening For Hyperlipidemia. New England Journal of Medicine. 329(15):1124-1128, Oct 7, 1993.
- Gould, K. Lance MD; Ornish, Dean MD; Scherwitz, Larry PhD; Brown, Shirley MD; Edens, R. Patterson PhD; Hess, Mary Jane RN; Mullani, Nizar; Bolomey, Leonard; Dobbs, Frank PhD; Armstrong, William T. MD; Merritt, Terri MS; Ports, Thomas MD; Sparler, Stephen MA; Billings, James PhD Changes in Myocardial Perfusion Abnormalities by Positron Emission Tomography After Long-term, Intense Risk Factor Modification. JAMA. 274(11):894-901, September 20, 1995.
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