Anisocytosis: Difference between revisions

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	*Anisocytosis with microcytosis – ], ]		*Anisocytosis with microcytosis – ], ]
	*Anisocytosis with macrocytosis – Folate or ], ], cytotoxic chemotherapy, ], ]		*Anisocytosis with macrocytosis – Folate or ], ], cytotoxic chemotherapy, ], ]
	Increased ] is seen in ]and decreased or normal in ] major (Cooley's anemia), thalassemia intermedia		Increased ] is seen in ] and decreased or normal in ] major (Cooley's anemia), thalassemia intermedia
	*Anisocytosis with normal RBC size – Early iron, vit B12 or folate deficiency, ], Sickle cell disease, chronic liver disease, Myelodysplastic syndrome<ref>{{EMedicine\|article\|2098635\|Red Cell Distribution Width (RDW)}}</ref>		*Anisocytosis with normal RBC size – Early iron, vit B12 or folate deficiency, ], Sickle cell disease, chronic liver disease, Myelodysplastic syndrome<ref>{{EMedicine\|article\|2098635\|Red Cell Distribution Width (RDW)}}</ref>

Revision as of 20:59, 15 December 2017

Medical condition

Anisocytosis

Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps. In addition, it is a characteristic feature of bovine blood.

The red cell distribution width (RDW) is a measurement of anisocytosis and is calculated as a coefficient of variation of the distribution of RBC volumes divided by the mean corpuscular volume (MCV)

Types

Anisocytosis is identified by RDW and is classified according to the size of RBC measured by MCV. According to this, it can be divided into

Anisocytosis with microcytosis – Iron deficiency, sickle cell anemia
Anisocytosis with macrocytosis – Folate or vitamin B₁₂ deficiency, autoimmune hemolytic anemia, cytotoxic chemotherapy, chronic liver disease, myelodysplastic syndrome

Increased RDW is seen in iron deficiency anemia and decreased or normal in thalassemia major (Cooley's anemia), thalassemia intermedia

Anisocytosis with normal RBC size – Early iron, vit B12 or folate deficiency, dimorphic anemia, Sickle cell disease, chronic liver disease, Myelodysplastic syndrome

References

Barbara J. Bain (2006). Blood cells: a practical guide. Wiley-Blackwell. pp. 66–. ISBN 978-1-4051-4265-6. Retrieved 10 November 2010.
Red Cell Distribution Width (RDW) at eMedicine

Blood film findings

Red blood cells

Size	Anisocytosis Macrocytosis Microcytosis
Shape	Poikilocytosis Membrane abnormalities Acanthocyte Codocyte Elliptocyte Hereditary elliptocytosis Spherocyte Hereditary spherocytosis Dacrocyte Echinocyte Schistocyte Degmacyte Sickle cell/drepanocyte Sickle cell disease Stomatocyte Hereditary stomatocytosis
Colour	Anisochromia Hypochromic anemia Polychromasia
Inclusion bodies	Developmental Howell–Jolly body Basophilic stippling Pappenheimer bodies Cabot rings Hemoglobin precipitation Heinz body
Other	Haemoconia Red cell agglutination Rouleaux

White blood cells

Lymphocytes	Reactive lymphocyte Smudge cell Russell bodies
Granulocytes	Hypersegmented neutrophil Arneth count Pelger–Huët anomaly Döhle bodies Toxic granulation Toxic vacuolation Critical green inclusion Alder–Reilly anomaly Jordans' anomaly Left shift
Other	Auer rod

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Revision as of 20:59, 15 December 2017

Types

See also

References