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⚫ '''Rhodanase''' (also '''Rhodanese''', '''Thiosulfate''' '''Sulfurtransferase''', '''Thiosulfate cyanide Transsulfurase'''; is a ] ], which is trasferred through sulfur of ] (S 2 O 3 -2) on ] (CN-). Thus the latter becomes ] (Thiocyanat, SCN -), while the Thiosulfate to ] (SO 3 -2) one reduces.
]


⚫ This reaction takes place in two steps. The diagram shows the radiographically determined structure of Rhodanase. Therein one can easily recognize a connection in the catalytic center of the enzyme. This is formed in the first step, by a , here Thiosulfat, its sulfur on ] group ]s-247-Restes '''1''' under education ]s '''2''' transfers. In the second step under recovery of the "normal" Thiol group the substrate, here cyanide, is sulfidiert:
⚫ ' the ' Rhodanase ' ' ' (also Rhodanese, Thiosulfat Sulfurtransferase, Thiosulfate cyanide Transsulfurase; ] ) is ] ], which sulfur of ] (S 2 O 3 -2) on ] (CN -) transfers. Thus the latter becomes ] (Thiocyanat, SCN -), while the Thiosulfate to ] (SO 3 -2) one reduces.


⚫ ]
⚫ This reaction takes place in two steps. The Abb. 1 shows the radiographically determined structure of the Rhodanase. Therein one can recognize a disulfide connection in the catalytic center of the enzyme very well. This is formed in the first step, by a sulfur donor, here Thiosulfate, its sulfur on ] group ]s-247-Restes ' ' ' 1 ' ' ' under education ]s ' ' ' 2 ' ' ' transfers. In the second step under recovery of the "normal" Thiol group the substrate, here cyanide, is sulfidiert:


⚫ This reaction is important for the decontamination of taken up cyanide, since the developing Thiocyanat is as far as possible innocuous. The administration of Thiosulfat (e.g. in form of one ] solution) with cyanide poisonings is based also on the activation of this enzymatic decontamination system. Vordergruendig seems to be this reaction the actual task of the Rhodanase; over its actual meaning so far no clarity prevails. A role as Schwefeldonor with the synthesis of ]n for ] is discussed.
⚫ ]

⚫ This reaction is important for the decontamination of cyanide, since the developing Thiocyanate is as far as possible innocuous. The administration of Thiosulfate (e.g. in form of one ] solution) with cyanide poisonings is based also on the activation of this enzymatic decontamination system. Vordergruendig seems to be this reaction the actual task of the Rhodanase; over its actual meaning so far no clarity prevails. A role as sulfur donor with the synthesis of ]n for ] is discussed.


==Literature== ==Literature==

Revision as of 23:10, 26 October 2006

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Rhodanase (also Rhodanese, Thiosulfate Sulfurtransferase, Thiosulfate cyanide Transsulfurase; is a mitochondriales enzyme, which is trasferred through sulfur of ] (S 2 O 3 -2) on cyanide (CN-). Thus the latter becomes Rhodanide (Thiocyanat, SCN -), while the Thiosulfate to sulfite (SO 3 -2) one reduces.

This reaction takes place in two steps. The diagram shows the radiographically determined structure of Rhodanase. Therein one can easily recognize a connection in the catalytic center of the enzyme. This is formed in the first step, by a , here Thiosulfat, its sulfur on Thiol group Cysteins-247-Restes 1 under education Disulfans 2 transfers. In the second step under recovery of the "normal" Thiol group the substrate, here cyanide, is sulfidiert:

This reaction is important for the decontamination of taken up cyanide, since the developing Thiocyanat is as far as possible innocuous. The administration of Thiosulfat (e.g. in form of one ] solution) with cyanide poisonings is based also on the activation of this enzymatic decontamination system. Vordergruendig seems to be this reaction the actual task of the Rhodanase; over its actual meaning so far no clarity prevails. A role as Schwefeldonor with the synthesis of ]n for ] is discussed.

Literature