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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 10:29, 21 November 2011 (Saving copy of the {{drugbox}} taken from revid 461556719 of page Tacrolimus for the Chem/Drugbox validation project (updated: 'UNII', 'ChEMBL').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 10:29, 21 November 2011 by Beetstra (talk | contribs) (Saving copy of the {{drugbox}} taken from revid 461556719 of page Tacrolimus for the Chem/Drugbox validation project (updated: 'UNII', 'ChEMBL').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
This page contains a copy of the infobox ({{drugbox}}) taken from revid 461556719 of page Tacrolimus with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
Pregnancy
category
  • C
Routes of
administration		Topical, oral, iv
ATC code
Pharmacokinetic data
Bioavailability20%, less after eating food rich in fat
Protein binding75-99%
MetabolismHepatic CYP3A4
Elimination half-life11.3 h (range 3.5-40.6 h)
ExcretionMostly faecal
Identifiers
IUPAC name
  • 3S-

    ,4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR
    -5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a
    -hexadecahydro-5, 19-dihydroxy
    -3-[2-(4-hydroxy-3-methoxycyclohexyl)
    -1-methylethenyl]-14,16-dimethoxy
    -4,10,12,18-tetramethyl-8-(2-propenyl)
    -15,19-epoxy-3H-pyrido oxaazacyclotricosine-1,7,20,21(4H,23H)

    -tetrone, monohydrate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
Chemical and physical data
FormulaC44H69NO12
Molar mass804.018 g/mol g·mol
3D model (JSmol)
SMILES
  • O=C3C(=O)N1CCCC1C(=O)O(C(=C/2CC(O)(OC)C2)/C)(C)(O)CC(=O)(/C=C(/C(C(OC)4O3(O)(C)C4OC)C)C)C\C=C
InChI
  • InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19-,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
  • Key:QJJXYPPXXYFBGM-LJIGMGMYSA-N
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