BOP reagent - Misplaced Pages

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BOP reagent
Names

IUPAC name Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate
Other names Castro's reagent
Identifiers
CAS Number	56602-33-6
3D model (JSmol)	Interactive image
ChemSpider	133386
ECHA InfoCard	100.054.782
PubChem CID	151348
CompTox Dashboard (EPA)	DTXSID60205170
InChI InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1Key: MGEVGECQZUIPSV-UHFFFAOYSA-N
SMILES F(F)(F)(F)(F)F.n1nn(O(N(C)C)(N(C)C)N(C)C)c2ccccc12
Properties
Chemical formula	C₁₂H₂₂F₆N₆OP₂
Molar mass	442.281 g/mol
Appearance	White crystalline powder
Melting point	136 - 140 °C
Solubility in water	Partially soluble in cold water
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is ?) Infobox references

Chemical compound

BOP-reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.

See also