Orbifloxacin - Misplaced Pages

This is an old revision of this page, as edited by AnomieBOT (talk | contribs) at 14:36, 29 September 2023 (Dating maintenance tags: {{Deadlink}}). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 14:36, 29 September 2023 by AnomieBOT (talk | contribs) (Dating maintenance tags: {{Deadlink}})(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Chemical compound Pharmaceutical compound

Orbifloxacin
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATCvet code	QJ01MA95 (WHO)
Legal status
Legal status	Veterinary use only
Identifiers
IUPAC name 1-Cyclopropyl-7--5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS Number	113617-63-3
PubChem CID	60605
ChemSpider	54631
UNII	660932TPY6
KEGG	D08299
ChEMBL	ChEMBL295433
CompTox Dashboard (EPA)	DTXSID7046201
ECHA InfoCard	100.166.510
Chemical and physical data
Formula	C₁₉H₂₀F₃N₃O₃
Molar mass	395.382 g·mol
3D model (JSmol)	Interactive image
SMILES O=C(O)C1=CN(C2CC2)c3c(C1=O)c(F)c(F)c(c3F)N4C(C)N(C)C4
InChI InChI=1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+ Key:QIPQASLPWJVQMH-DTORHVGOSA-N
(what is this?) (verify)

Orbifloxacin (brand name Orbax) is a fluoroquinolone antibiotic which is approved for use in dogs, marketed by Schering-Plough Animal Health.

References

"Product Abstract - NADA 141-081". American College of Veterinary Clinical Pharmacology. Retrieved 21 June 2008.
Papich MG (October 2020). "Orbifloxacin". Papich Handbook of Veterinary Drugs (Fifth ed.). St. Louis, Missouri: Elsevier Health Sciences. p. 674. ISBN 978-0-323-70958-3.

Antibacterials that inhibit nucleic acid (J01E, J01M)

Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)

DHFR inhibitor

2,4-Diaminopyrimidine

Sulfonamides
(DHPS inhibitor)

Short-acting	Sulfaisodimidine Sulfamethizole Sulfadimidine (Sulfamethazine, Sulfadimerazine, Sulfadimezine) Sulfapyridine (Sulfasalazine) Sulfafurazole (Acetyl sulfisoxazole) Sulfanilamide Prontosil Sulfathiazole (Phthalylsulfathiazole, Succinylsulfathiazole) Sulfathiourea
Intermediate-acting	Sulfamethoxazole Sulfadiazine Sulfamoxole
Long-acting	Sulfadimethoxine Sulfadoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone
Other/ungrouped	Mafenide Sulfacetamide Sulfaclozine Sulfadicramide Sulfaguanidine Sulfametrole Sulfanitran

Combinations

Other DHPS inhibitors

Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)

1st generation

Fluoroquinolones

2nd generation	Ciprofloxacin Ofloxacin Enoxacin Fleroxacin Lomefloxacin Nadifloxacin/Levonadifloxacin/Alalevonadifloxacin Norfloxacin Pefloxacin Rufloxacin
3rd generation	Levofloxacin Balofloxacin Grepafloxacin Pazufloxacin Sparfloxacin Temafloxacin Tosufloxacin
4th generation	Besifloxacin Delafloxacin Gatifloxacin Finafloxacin Gemifloxacin Moxifloxacin Clinafloxacin Garenoxacin Prulifloxacin Sitafloxacin Trovafloxacin/Alatrofloxacin
Veterinary	Danofloxacin Difloxacin Enrofloxacin Ibafloxacin Marbofloxacin Orbifloxacin Pradofloxacin Sarafloxacin

Newer non-fluorinated

Related (DG)

Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitroimidazole derivatives	Secnidazole

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin Rifabutin Rifapentine Rifaximin Rifalazil
Lipiarmycins	Fidaxomicin

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

This systemic antibiotic-related article is a stub. You can help Misplaced Pages by expanding it.

This veterinary medicine–related article is a stub. You can help Misplaced Pages by expanding it.

Categories:

See also

References