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• An abbreviation of October, the tenth month of the year in the Gregorian calendar
• Optical coherence tomography an imaging technology using light
• Optical Current Transformer an sensor which use optics technology to measure the current
• OCT, the professional designation granted to certified teachers in Ontario
• OCT the Microsoft Office Customisation Tool, available in some version distributions of the Microsoft Office 2007 product. Refer to http://technet.microsoft.com/en-us/library/cc179097.aspx for details.
• Odd Cycle Transversal, a graph theoretic and algorithmic problem in mathematics
• Octal, the numeral system
• Octans, a constellation
• On chip termination, for terminating communication lines in integrated electronics.
• Optical coherence tomography, an interferometric three dimensional imaging method used in (e.g.) ophthalmology
• Optimal cutting temperature compound or O.C.T., for embedding tissues to be cryosectioned
• Organic Cation Transporter
• Orion Correlation Theory, a pseudoarchaeological explanation for the groundplan layout of the pyramids at Giza, advanced by writers such as Robert Bauval, Graham Hancock and Adrian Gilbert
• Ornithine Carbamoyltransferase Deficiency
• Overseas Chinese Town, a theme park in Shenzhen, China
• Overseas countries and territories, twenty territories that have a special relationship with one of the member states of the EU
• Oxford Classical Texts
• Oxytocin challenge test
• Oct, a fictional species from The Culture
• Octahedron
• Oral Contraceptive Therapy
• Office of the Chief Technologist, a position and associated bureau in NASA

• Disambiguation pages