Misplaced Pages

This is an old revision of this page, as edited by JohnDoe0007 (talk | contribs) at 12:16, 14 February 2007 (corrected an incorrect redirect). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

The Warburg effect is the inhibition of carbon dioxide fixation, and subsequently photosynthesis, by high oxygen concentrations. The effect is named for Otto Heinrich Warburg. The oxygenase activity of RuBisCO, which initiates the process of photorespiration, largely accounts for the Warburg effect. In humans, the Warburg Effect causes cancer cells to rely preferentially on glycolysis for adenosine triphosphate (ATP) production unlike normal healthy cells. Because nicotinamide adenine dinucleotide (NAD) is a cofactor required for glycolysis, by blocking the production of NAD the cancerous cell will eventually die apoptotically. This allows for the creation of chemotherapy drugs by targeting specific fast growing, NAD reliant cells.

This biochemistry article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Biochemistry stubs
• Photosynthesis
• Oncology
• Biochemistry