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TAN-1057 A

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TAN-1057 (A, B)

TAN-1057 A

TAN-1057 B
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C13H25N9O3/c1-22(8-6-19-13(20-10(8)24)21-12(17)25)9(23)5-7(14)3-2-4-18-11(15)16/h7-8H,2-6,14H2,1H3,(H4,15,16,18)(H4,17,19,20,21,24,25)/t7-,8+/m0/s1Key: ZMWBCGMRXBPXEU-JGVFFNPUSA-N
  • InChI=1/C13H25N9O3/c1-22(8-6-19-13(20-10(8)24)21-12(17)25)9(23)5-7(14)3-2-4-18-11(15)16/h7-8H,2-6,14H2,1H3,(H4,15,16,18)(H4,17,19,20,21,24,25)/t7-,8+/m0/s1Key: ZMWBCGMRXBPXEU-JGVFFNPUBF
SMILES
  • O=C1N\C(=N/C1N(C(=O)C(N)CCC/N=C(\N)N)C)NC(=O)N
Properties
Chemical formula C13H25N9O3
Molar mass 355.403 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

TAN-1057 A and TAN-1057 B are organic compounds found in the Flexibacter sp. PK-74 bacterium. TAN-1057 A and B are closely related structurally as diastereomers. Also related are TAN-1057 C and TAN-1057 D, isolated from the same bacteria. The four compounds have been shown to be an effective antibiotics against methicillin-resistant strains of Staphylococcus aureus which act through the inhibition of protein biosynthesis.

References

  1. Katayama, N; et al. (1993). "TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity". J. Antibiot. 46 (4): 606–613. doi:10.7164/antibiotics.46.606. PMID 8501003.


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